Document Detail

Brain growth in preterm infants is affected by the degree of growth restriction at birth.
MedLine Citation:
PMID:  23131060     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Documentation of examination of brain structural development by magnetic resonance imaging (MRI) beyond the neonatal period is scarce for both preterm and small for gestational age (SGA) infants.
AIM: To investigate structural brain development during infancy in preterm children born SGA by MRI.
METHODS: A total of 205 preterm infants, 139 appropriate for gestational age (AGA) and 66 SGA, of which 33 had birth weight (BW) < 3rd percentile and 33 had BW 3rd-10th percentile, were examined prospectively by brain MRI at the corrected age of 5 months. The total volume of the brain, ventricles and cerebellum, the area of vermis and corpus callosum, and the height of the pituitary, mesencephalon and pons were estimated on MRI.
RESULTS: Brain volume was smaller in the SGA < 3rd percentile infants, independent of other perinatal factors. Chronic lung disease was an independent predictor of low brain volume. Pituitary height was greater in SGA < 3rd percentile than in AGA infants. The corpus callosum area was less in SGA < 3rd percentile than in SGA of 3rd-10th percentile infants.
CONCLUSIONS: Preterm infants born SGA with BW < 3rd percentile had differences in brain structural measurements at the corrected age of 5 months, compared with preterm AGA infants, which could have implications for their neurocognitive development.
Vasileios Xydis; Aikaterini Drougia; Vasileios Giapros; Maria Argyropoulou; Styliani Andronikou
Publication Detail:
Type:  Journal Article     Date:  2012-12-14
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  26     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-05     Completed Date:  2014-01-09     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  673-9     Citation Subset:  IM    
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MeSH Terms
Brain / growth & development*
Infant, Newborn
Infant, Premature / growth & development*
Infant, Small for Gestational Age / growth & development*
Magnetic Resonance Imaging
Regression Analysis

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