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Brain growth in preterm infants is affected by the degree of growth restriction at birth.
MedLine Citation:
PMID:  23131060     Owner:  NLM     Status:  Publisher    
Abstract Objective: Documentation of examination of brain structural development by MRI beyond the neonatal period is scarce for both preterm and small for gestational age (SGA) infants. Aim: To investigate by MRI structural brain development during infancy in preterm children born SGA. Methods: A total of 205 preterm infants, 139 appropriate for GA (AGA) and 66 SGA, of which 33 had birth weight (BW)<3(rd) percentile and 33 had BW 3(rd)-10(th) percentile, were examined prospectively by brain MRI at the corrected age of 5 months. The total volume of the brain, ventricles and cerebellum, the area of vermis and corpus callosum, and the height of the pituitary, mesencephalon and pons were estimated on MRI. Results: Brain volume was smaller in the SGA<3(rd) percentile infants, independent of other perinatal factors. Chronic lung disease was an independent predictor of low brain volume. Pituitary height was greater in SGA<3(rd) percentile than in AGA infants. The corpus callosum area was less in SGA<3(rd) percentile than in SGA 3(rd)-10(th) percentile infants. Conclusions: Preterm infants born SGA with BW<3(rd) percentile had differences in brain structural measurements at the corrected age of 5 months, compared with preterm AGA infants, which could have implications for their neurocognitive development.
Xydis Vasileios; Drougia Aikaterini; Giapros Vasileios; Argyropoulou Maria; Andronikou Styliani
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-6
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Radiology Department.
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