Document Detail


Brain growth among fetuses exposed to cocaine in utero: asymmetrical growth retardation.
MedLine Citation:
PMID:  1992399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal growth retardation may be associated with maternal cocaine use during pregnancy. The pattern of fetal growth retardation was analyzed in infants born to 80 women who used cocaine, but not alcohol, during pregnancy, and in two comparison groups: 100 infants born to mothers who used neither alcohol nor cocaine during pregnancy and 67 infants whose mothers used alcohol but not cocaine during pregnancy. There were statistically significant differences in head size between the unexposed and cocaine-exposed infants (P less than .001). Notably, head circumference was reduced proportionately more than birth weight in cocaine-exposed infants, a pattern similar to that observed in alcohol-exposed infants. Alcohol- and cocaine-exposed infants were not statistically different in head circumference. We conclude that brain growth of cocaine-exposed infants is similar to that reported for alcohol-exposed infants, and that cocaine-exposed infants may be characterized as having asymmetrical growth retardation.
Authors:
B B Little; L M Snell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  77     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-03-13     Completed Date:  1991-03-13     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-4     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas.
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MeSH Terms
Descriptor/Qualifier:
Alcohol Drinking
Birth Weight
Brain / drug effects*,  embryology
Cephalometry
Cocaine / adverse effects*
Female
Fetal Growth Retardation / chemically induced*,  pathology
Humans
Infant, Newborn
Pregnancy*
Regression Analysis
Substance-Related Disorders / complications*
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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