| Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats. | |
| | |
MedLine Citation:
|
PMID: 20179723 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading. |
| | |
Authors:
|
Tiziana Liistro; Letizia Guiducci; Silvia Burchielli; Daniele Panetta; Nicola Belcari; Silvia Pardini; Alberto Del Guerra; Piero A Salvadori; Patricia Iozzo |
Related Documents
:
|
19812703 - Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamu... 7414663 - Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ischemia i... 20222813 - Loss-of-function cyp2c9 variants: finding the correct clinical role for type 2 diabetes... |
Publication Detail:
|
Type: Journal Article Date: 2010-02-24 |
Journal Detail:
|
Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-05-03 Completed Date: 2010-05-27 Revised Date: 2011-07-28 |
Medline Journal Info:
|
Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
|
Languages: eng Pagination: 895-9 Citation Subset: IM |
Affiliation:
|
Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Glucose / metabolism* Brain / anatomy & histology, metabolism* Diabetes Mellitus, Type 2* / metabolism, physiopathology, radionuclide imaging Fasting Fluorodeoxyglucose F18 / metabolism* Male Obesity* / metabolism, physiopathology, radionuclide imaging Positron-Emission Tomography Rats Rats, Zucker* |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 63503-12-8/Fluorodeoxyglucose F18 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel oral anticoagulants to prevent stroke in atrial fibrillation.
Next Document: Brain nonoxidative carbohydrate consumption is not explained by export of an unknown carbon source: ...