Document Detail


Brain gangliosides in monotremes, marsupials and placentals: phylogenetic and thermoregulatory aspects.
MedLine Citation:
PMID:  3943299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration and composition of brain gangliosides of 17 mammalian species belonging to the subclasses of Prototheria (monotremes), Metatheria (marsupials), and Eutheria (placentals) were investigated. The mean concentration of brain gangliosides ranges from 525 to 610 micrograms NeuAc/g wet wt in monotremes, 445-900 micrograms in marsupials and from 630 to 1130 micrograms in the placentals. In the phylogenetic series of mammals, a decrease in the complexity of brain ganglioside composition becomes obvious: a drastic reduction in the number of individual ganglioside fractions particularly those of the c-pathway of biosynthesis, took place from the level of monotremes to that of the marsupials and placentals. In monotremes, marsupials and "lower" placentals (insectivores) the percentage of alkali-labile gangliosides is relatively low (between traces and 5%), whereas in the higher evolved mammals it amounts to about 20% of all gangliosides. The ratio of the contents of the two major mammalian ganglioside fractions GD1a and GT1b is generally in the range of 1.0 and even higher; in the heterothermic platypus from the monotremes and in hibernators among the placental mammals, however, it is much lower (about 0.8). These data support the hypothesis that the brain ganglioside composition not only depends on the phylogenetic level of nervous organization (cephalization) but is additionally correlated with the state of thermal adaptation.
Authors:
H Rahmann; R Hilbig; F Geiser
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. B, Comparative biochemistry     Volume:  83     ISSN:  0305-0491     ISO Abbreviation:  Comp. Biochem. Physiol., B     Publication Date:  1986  
Date Detail:
Created Date:  1986-03-26     Completed Date:  1986-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984730R     Medline TA:  Comp Biochem Physiol B     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  151-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Chemistry*
Gangliosides / analysis*
Mammals / genetics*
Marsupialia / genetics*
Phylogeny*
Species Specificity
Chemical
Reg. No./Substance:
0/Gangliosides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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