| Brain enzyme and clinical alterations induced in rats and mice by nitroaliphatic toxicants. | |
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MedLine Citation:
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PMID: 4060188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of a single subcutaneous (s.c.) injection of the nitroaliphatic toxicants 3-nitropropanol (NPOH) and 3-nitropropionic acid (NPA) dissolved in physiological saline solution were studied in mice and rats, respectively. Clinical signs observed in both NPOH-treated mice and NPA-treated rats included depression, abnormal motor activity, and recumbency. Succinate dehydrogenase (SDH) activity, demonstrated histochemically in frozen brain sections, was markedly reduced in intoxicated mice and rats. The SDH activity of mitochondrial preparations from brains of intoxicated mice and rats was diminished to 18-24% of control values, although the activity of another mitochondrial flavoprotein enzyme, alpha-glycerophosphate dehydrogenase (alpha-GPDH), was not altered. |
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Authors:
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D H Gould; M P Wilson; D W Hamar |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Toxicology letters Volume: 27 ISSN: 0378-4274 ISO Abbreviation: Toxicol. Lett. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-11-25 Completed Date: 1985-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7709027 Medline TA: Toxicol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 83-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Propanol
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metabolism,
toxicity Animals Brain / drug effects*, enzymology Female Glycerolphosphate Dehydrogenase / analysis Male Mice Motor Activity / drug effects Nitro Compounds Propanols* Propionates / toxicity* Propionic Acids / toxicity* Rats Rats, Inbred Strains Succinate Dehydrogenase / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Nitro Compounds; 0/Propanols; 0/Propionates; 0/Propionic Acids; 25182-84-7/3-nitro-1-propanol; 504-88-1/3-nitropropionic acid; 71-23-8/1-Propanol; EC 1.1.-/Glycerolphosphate Dehydrogenase; EC 1.3.99.1/Succinate Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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