| Brain enlargement and increased behavioral and cytokine reactivity in infant monkeys following acute prenatal endotoxemia. | |
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MedLine Citation:
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PMID: 21192986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infections and inflammatory conditions during pregnancy can dysregulate neural development and increase the risk for developing autism and schizophrenia. The following research utilized a nonhuman primate model to investigate the potential impact of a mild endotoxemia during pregnancy on brain maturation and behavioral reactivity as well as the infants' hormone and immune physiology. Nine pregnant female rhesus monkeys (Macaca mulatta) were administered nanogram concentrations of lipopolysaccharide (LPS) on two consecutive days, 6 weeks before term, and their offspring were compared to nine control animals. When tested under arousing challenge conditions, infants from the LPS pregnancies were more behaviorally disturbed, including a failure to show a normal attenuation of startle responses on tests of prepulse inhibition. Examination of their brains at 1 year of age with magnetic resonance imaging (MRI) revealed the unexpected finding of a significant 8.8% increase in global white matter volume distributed across many cortical regions compared to controls. More selective changes in regional gray matter volume and cortical thickness were noted in parietal, medial temporal, and frontal areas. While inhibited neural growth has been described previously after prenatal infection and LPS administration at higher doses in rodents, this low dose endotoxemia in the monkey is the first paradigm to produce a neural phenotype associated with augmented gray and white matter growth. |
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Authors:
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Auriel A Willette; Gabriele R Lubach; Rebecca C Knickmeyer; Sarah J Short; Martin Styner; John H Gilmore; Christopher L Coe |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-12-27 |
Journal Detail:
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Title: Behavioural brain research Volume: 219 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-22 Completed Date: 2011-07-13 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 108-15 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Harlow Primate Laboratory, University of Wisconsin, Madison, WI 53715, USA. AAWillette@medicine.wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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psychology Animals Anxiety / psychology Attention / drug effects Behavior, Animal / drug effects* Brain / anatomy & histology, drug effects, growth & development* Cerebral Cortex / drug effects, growth & development Cytokines / metabolism* Emotions / drug effects Endotoxemia / psychology* Female Humans Hydrocortisone / metabolism Image Processing, Computer-Assisted Immune System / drug effects Injections, Intraventricular Interleukin-6 / metabolism Interpersonal Relations Lipopolysaccharides / administration & dosage, pharmacology Macaca mulatta Magnetic Resonance Imaging Neurosecretory Systems / drug effects, metabolism Pregnancy Prenatal Exposure Delayed Effects / chemically induced, pathology*, psychology Startle Reaction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AI067518/AI/NIAID NIH HHS; HD03110/HD/NICHD NIH HHS; IUL1RR025011/RR/NCRR NIH HHS; MH064065/MH/NIMH NIH HHS; P30 HD003110-40/HD/NICHD NIH HHS; P50 MH064065-10/MH/NIMH NIH HHS; R01 AI067518-05/AI/NIAID NIH HHS; UL1 RR025011-05/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukin-6; 0/Lipopolysaccharides; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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