Document Detail


Brain enlargement and increased behavioral and cytokine reactivity in infant monkeys following acute prenatal endotoxemia.
MedLine Citation:
PMID:  21192986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Infections and inflammatory conditions during pregnancy can dysregulate neural development and increase the risk for developing autism and schizophrenia. The following research utilized a nonhuman primate model to investigate the potential impact of a mild endotoxemia during pregnancy on brain maturation and behavioral reactivity as well as the infants' hormone and immune physiology. Nine pregnant female rhesus monkeys (Macaca mulatta) were administered nanogram concentrations of lipopolysaccharide (LPS) on two consecutive days, 6 weeks before term, and their offspring were compared to nine control animals. When tested under arousing challenge conditions, infants from the LPS pregnancies were more behaviorally disturbed, including a failure to show a normal attenuation of startle responses on tests of prepulse inhibition. Examination of their brains at 1 year of age with magnetic resonance imaging (MRI) revealed the unexpected finding of a significant 8.8% increase in global white matter volume distributed across many cortical regions compared to controls. More selective changes in regional gray matter volume and cortical thickness were noted in parietal, medial temporal, and frontal areas. While inhibited neural growth has been described previously after prenatal infection and LPS administration at higher doses in rodents, this low dose endotoxemia in the monkey is the first paradigm to produce a neural phenotype associated with augmented gray and white matter growth.
Authors:
Auriel A Willette; Gabriele R Lubach; Rebecca C Knickmeyer; Sarah J Short; Martin Styner; John H Gilmore; Christopher L Coe
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-12-27
Journal Detail:
Title:  Behavioural brain research     Volume:  219     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-07-13     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  108-15     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
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MeSH Terms
Descriptor/Qualifier:
Aging / psychology
Animals
Anxiety / psychology
Attention / drug effects
Behavior, Animal / drug effects*
Brain / anatomy & histology,  drug effects,  growth & development*
Cerebral Cortex / drug effects,  growth & development
Cytokines / metabolism*
Emotions / drug effects
Endotoxemia / psychology*
Female
Humans
Hydrocortisone / metabolism
Image Processing, Computer-Assisted
Immune System / drug effects
Injections, Intraventricular
Interleukin-6 / metabolism
Interpersonal Relations
Lipopolysaccharides / administration & dosage,  pharmacology
Macaca mulatta
Magnetic Resonance Imaging
Neurosecretory Systems / drug effects,  metabolism
Pregnancy
Prenatal Exposure Delayed Effects / chemically induced,  pathology*,  psychology
Startle Reaction / physiology
Grant Support
ID/Acronym/Agency:
AI067518/AI/NIAID NIH HHS; HD03110/HD/NICHD NIH HHS; IUL1RR025011/RR/NCRR NIH HHS; MH064065/MH/NIMH NIH HHS; P30 HD003110/HD/NICHD NIH HHS; P30 HD003110-40/HD/NICHD NIH HHS; P50 MH064065/MH/NIMH NIH HHS; P50 MH064065-10/MH/NIMH NIH HHS; R01 AI067518/AI/NIAID NIH HHS; R01 AI067518-05/AI/NIAID NIH HHS; R01 MH091645/MH/NIMH NIH HHS; UL1 RR025011/RR/NCRR NIH HHS; UL1 RR025011-05/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/Lipopolysaccharides; WI4X0X7BPJ/Hydrocortisone
Comments/Corrections

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