| Brain energy metabolism in angiotensin-induced acute hypertension in rats. | |
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MedLine Citation:
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PMID: 888709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to study if rapid elevation of blood pressure is associated with cerebral ischemia, anesthetized (70% N2O) and artificially ventilated rats were subjected to angiotensin-induced hypertension. After a 5 min hypertensive period, cerebral cortex tissue was frozen in situ for subsequent measurements of labile glycolytic metabolites, ammonia, and organic phosphates. The degree of hypertension induced, which gave evidence of blood-brain barrier damage in 7 of 8 rats, did not affect the tissue concentrations of labile metabolites. It is concluded that ischemia does not contribute to the barrier damage, nor is it likely to be the cause of the clinical symptoms that may occur in conscious rats in the same experimental model. |
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Authors:
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B B Johansson; B K Siesjö |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 100 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 1977 Jun |
Date Detail:
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Created Date: 1977-09-29 Completed Date: 1977-09-29 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 182-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Ammonia / metabolism Angiotensin II* Animals Blood-Brain Barrier Brain / metabolism* Energy Metabolism* / drug effects Glucose / metabolism Glycogen / metabolism Hypertension / chemically induced, metabolism* Ischemic Attack, Transient / etiology, metabolism Male Organophosphorus Compounds / metabolism Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Organophosphorus Compounds; 11128-99-7/Angiotensin II; 50-99-7/Glucose; 7664-41-7/Ammonia; 9005-79-2/Glycogen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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