Document Detail

Brain electrical activity (EEG) after repetitive exposure to chlorphenvinphos an organophosphate anticholinesterase: I. Rabbit.
MedLine Citation:
PMID:  2132936     Owner:  NLM     Status:  MEDLINE    
Cholinesterase (ChE) activity in blood and brain as well as the hippocampal and cortical EEG were investigated in rabbits exposed once a day for a period of two weeks to an organophosphate insecticide, chlorphenvinphos (CVP). The daily dose of CVP was 14.0 mg/kg i.p. ChE activity in plasma and erythrocytes decreased by 60 and 48%, respectively, by the end of exposure and returned to the preexposure level within 35 days. In the exposed animals, killed and dissected a day after, the ChE activity in blood had been found normal, the level of ChE activity in some parts of the brain was still significantly depressed. The spontaneous hippocampal EEG showed no changes as soon as 24 hours after the exposure. However, after a period sufficiently long for the normalization of ChE activity in blood, the hippocampal arousal response (theta rhythm) to click and to a tone associated with pain was found heightened in the exposed rabbits. Moreover, spectral analysis of 5 minute EEG samples revealed a decrease in the content of 7-13 Hz activity in the cortex of the exposed animals as compared to the control ones. The obtained data suggest that exposure to CVP may lead to functional changes in the brain outlasting the period of ChE depression.
S Gralewicz; W Kowalczyk; R Górny; R Soćko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Polish journal of occupational medicine     Volume:  3     ISSN:  0860-6536     ISO Abbreviation:  Pol J Occup Med     Publication Date:  1990  
Date Detail:
Created Date:  1992-02-21     Completed Date:  1992-02-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9012925     Medline TA:  Pol J Occup Med     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  51-67     Citation Subset:  IM    
Department of Toxicity Evaluation, Nofer Institute of Occupational Medicine, Lodz, Poland.
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MeSH Terms
Brain / drug effects*,  enzymology
Chlorfenvinphos / toxicity*
Cholinesterases / metabolism
Electroencephalography / drug effects*
Environmental Exposure*
Hippocampus / drug effects
Reg. No./Substance:
470-90-6/Chlorfenvinphos; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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