Document Detail


Brain dopamine and obesity.
MedLine Citation:
PMID:  11210998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The cerebral mechanisms underlying the behaviours that lead to pathological overeating and obesity are poorly understood. Dopamine, a neurotransmitter that modulates rewarding properties of food, is likely to be involved. To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D2 receptors in brain. METHODS: Brain dopamine D2 receptor availability was measured with positron emission tomography (PET) and [C-11]raclopride (a radioligand for the dopamine D2 receptor). Bmax/Kd (ratio of the distribution volumes in striatum to that in cerebellum minus 1) was used as a measure of dopamine D2 receptor availability. Brain glucose metabolism was also assessed with 2-deoxy-2[18F]fluoro-D-glucose (FDG). FINDINGS: Striatal dopamine D2 receptor availability was significantly lower in the ten obese individuals (2.47 [SD 0.36]) than in controls (2.99 [0.41]; p < or = 0.0075). In the obese individuals body mass index (BMI) correlated negatively with the measures of D2 receptors (r=0.84; p < or = 0.002); the individuals with the lowest D2 values had the largest BMI. By contrast, neither whole brain nor striatal metabolism differed between obese individuals and controls, indicating that striatal reductions in D2 receptors were not due to a systematic reduction in radiotracer delivery. INTERPRETATION: The availability of dopamine D2 receptor was decreased in obese individuals in proportion to their BMI. Dopamine modulates motivation and reward circuits and hence dopamine deficiency in obese individuals may perpetuate pathological eating as a means to compensate for decreased activation of these circuits. Strategies aimed at improving dopamine function may be beneficial in the treatment of obese individuals.
Authors:
G J Wang; N D Volkow; J Logan; N R Pappas; C T Wong; W Zhu; N Netusil; J S Fowler
Related Documents :
16879758 - Antipsychotic-like effect by combined treatment with citalopram and way 100635: involve...
15735658 - Mechanisms of inverse agonist action at d2 dopamine receptors.
8318718 - The competitive and noncompetitive antagonism of receptor-mediated drug actions in the ...
1312848 - Differential g protein-mediated coupling of d2 dopamine receptors to k+ and ca2+ curren...
16001968 - Characterization of a novel d2-like dopamine receptor with a truncated splice variant a...
8390248 - Neurotransmitter release from lysophosphatidic acid stimulated pc12 cells: involvement ...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  357     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-08     Completed Date:  2001-02-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  354-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA. giwang@bnl.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Brain Mapping
Case-Control Studies
Cerebellum / metabolism*
Corpus Striatum / metabolism*
Female
Glucose / metabolism
Humans
Linear Models
Male
Middle Aged
Obesity / metabolism*
Receptors, Dopamine D2 / metabolism*
Tomography, Emission-Computed
Grant Support
ID/Acronym/Agency:
DA 06891-02/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Dopamine D2; 50-99-7/Glucose
Comments/Corrections
Comment In:
Lancet. 2001 Jun 9;357(9271):1883   [PMID:  11417577 ]
Lancet. 2001 Jun 9;357(9271):1883   [PMID:  11417578 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Observations on recurrent syncope and presyncope in 641 patients.
Next Document:  Pseudoexfoliation syndrome and aneurysms of the abdominal aorta.