Document Detail

Brain dopamine as a target for solvent toxicity: effects of some monocyclic aromatic hydrocarbons.
MedLine Citation:
PMID:  3376126     Owner:  NLM     Status:  MEDLINE    
Adult male rabbits were exposed to toluene, xylene, styrene, ethylbenzene, vinyltoluene or were dosed with hippuric, methylhippuric, mandelic, phenylglyoxylic, and 7-methyl-mandelic acids. Styrene, vinyltoluene and ethylbenzene caused a marked depletion of striatal and tubero-infundibular dopamine. Such an effect was also caused by treatment with mandelic and phenylglyoxylic acids. These results indicate that dopamine is a target for some solvents of their metabolites, the presence of a lateral vinyl- or ethyl-chain which may be biotransformed into alpha-keto acids being crucial for the effect. Experiments in vitro suggest that dopamine condenses non-enzymatically with reactive carbonylic groups of such and other alpha-keto acids, thus becoming ineffective as neurotransmitter. This mechanism might account for the neurobehavioral and neuroendocrine changes which have been reported in workers occupationally exposed to styrene and to some solvent mixtures.
A Mutti; M Falzoi; A Romanelli; M C Bocchi; C Ferroni; I Franchini
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology     Volume:  49     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Institute of Clinical Medicine and Nephrology, Chair of Occupational Medicine, University of Parma, Italy.
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MeSH Terms
Arcuate Nucleus / drug effects,  metabolism
Chromatography, High Pressure Liquid
Corpus Striatum / drug effects*,  metabolism
Dopamine / metabolism*
Norepinephrine / metabolism*
Solvents / toxicity*
Styrenes / toxicity*
Reg. No./Substance:
0/Solvents; 0/Styrenes; 100-42-5/Styrene; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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