Document Detail


Brain dopamine as a target for solvent toxicity: effects of some monocyclic aromatic hydrocarbons.
MedLine Citation:
PMID:  3376126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult male rabbits were exposed to toluene, xylene, styrene, ethylbenzene, vinyltoluene or were dosed with hippuric, methylhippuric, mandelic, phenylglyoxylic, and 7-methyl-mandelic acids. Styrene, vinyltoluene and ethylbenzene caused a marked depletion of striatal and tubero-infundibular dopamine. Such an effect was also caused by treatment with mandelic and phenylglyoxylic acids. These results indicate that dopamine is a target for some solvents of their metabolites, the presence of a lateral vinyl- or ethyl-chain which may be biotransformed into alpha-keto acids being crucial for the effect. Experiments in vitro suggest that dopamine condenses non-enzymatically with reactive carbonylic groups of such and other alpha-keto acids, thus becoming ineffective as neurotransmitter. This mechanism might account for the neurobehavioral and neuroendocrine changes which have been reported in workers occupationally exposed to styrene and to some solvent mixtures.
Authors:
A Mutti; M Falzoi; A Romanelli; M C Bocchi; C Ferroni; I Franchini
Related Documents :
12662356 - Simple and stereospecific homologation of urethane-protected alpha-amino acids to their...
7142816 - Bile acids. lxvii. the major bile acids of varanus monitor.
10705486 - The dakin-west reaction of n-alkoxycarbonyl-n-alkyl-alpha-amino acids employing trifluo...
1707236 - Rosenthal fibers share epitopes with alpha b-crystallin, glial fibrillary acidic protei...
17258836 - Biodegradable in situ gelling system for subcutaneous administration of ellagic acid an...
15848196 - The faxwxxt motif in the carboxyl terminus of vibrio mimicus metalloprotease is involve...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology     Volume:  49     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
Affiliation:
Institute of Clinical Medicine and Nephrology, Chair of Occupational Medicine, University of Parma, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Arcuate Nucleus / drug effects,  metabolism
Chromatography, High Pressure Liquid
Corpus Striatum / drug effects*,  metabolism
Dopamine / metabolism*
Male
Norepinephrine / metabolism*
Rabbits
Solvents / toxicity*
Styrene
Styrenes / toxicity*
Chemical
Reg. No./Substance:
0/Solvents; 0/Styrenes; 100-42-5/Styrene; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Lead stimulates Golgi sialyltransferase at times coincident with the embryonic to adult conversion o...
Next Document:  The toxic effect of an AChE-inhibitor on the cholinergic nervous system in airway smooth muscle.