Document Detail

Brain docosahexaenoic acid status and learning in young rats submitted to dietary long-chain polyunsaturated fatty acid deficiency and supplementation limited to lactation.
MedLine Citation:
PMID:  15718358     Owner:  NLM     Status:  MEDLINE    
N-3 fatty acid deficiency has been related to decreased docosahexaenoic acid (DHA) and increased docosapentaenoic acid (DPA) levels in brain and to learning disadvantages. The influence of n-3 deficiency and supplementation on brain fatty acids and learning were investigated in young rats. Newborn Wistar rats were assigned to three groups of cross-foster mothers. The control group (C) was nursed by mothers that received essential fatty acids during pregnancy and lactation, and the deficient group (D) was nursed by mothers that did not receive those fatty acids. The supplemental group (S) had the same conditions as D, receiving an additional DHA and arachidonic acid supplement during lactation. Cerebral cortex and hippocampus fatty acid composition was examined using thin-layer and capillary column gas chromatography, and learning was measured by passive-avoidance procedure. D brains showed low DHA and high DPA levels, but S brain composition was similar to C. Learning in the S group was unaffected, but in the D group, it was poorer than C. Learning was directly correlated with DHA levels and inversely with DPA levels in brain. Low DHA and high DPA brain levels both were correlated with poor learning. DPA seems not to be a suitable brain functional analogue of DHA, and DHA supplementation reversed both biochemical and learning adverse effects observed in n-3 deficiency.
Salvador García-Calatayud; Carlos Redondo; Eva Martín; José Ignacio Ruiz; Miguel García-Fuentes; Pablo Sanjurjo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-02-17
Journal Detail:
Title:  Pediatric research     Volume:  57     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-22     Completed Date:  2005-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-23     Citation Subset:  IM    
Department of Pediatrics, University of Cantabria, 39011 Santander, Cantabria, Spain.
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MeSH Terms
Animals, Newborn
Avoidance Learning
Brain / drug effects,  metabolism*
Cerebral Cortex / metabolism
Chromatography, Gas
Dietary Supplements*
Docosahexaenoic Acids / metabolism*
Fatty Acids / metabolism
Fatty Acids, Unsaturated / deficiency*,  pharmacology
Hippocampus / metabolism
Lipid Metabolism
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids; 25448-00-4/docosapentaenoic acid

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