| Brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus with new acute neurological symptoms. | |
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MedLine Citation:
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PMID: 17729344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the source of significant difference in apparent diffusion coefficient (ADC) between patients with acute symptoms of neuropsychiatric (NP) systematic lupus erythematosus (SLE) (NPSLE) and normal controls. MATERIALS AND METHODS: Diffusion-weighted echo-planar imaging was performed on 1.5-T scanners in 17 female and four male NPSLE patients with acute neurological symptoms (23-76 years, mean = 42.7 years), and in 21 aged-matched healthy controls (16 female, five male, 26-63 years, mean = 41.1 years). ADC histograms were calculated for whole brain, gray matter tissue, and white matter tissue. RESULTS: Of the 17 NPSLE patients, 13 (72%) had abnormal findings on MR imaging. The NPSLE patients had a mean ADC value of (1105.1 +/- 23.6) x 10(-6) mm(2)/second and the control had a mean ADC value of (1012.5 +/- 9.4) x 10(-6) mm(2)/second (P < or = 0.0012). Significant differences were also found in white matter (P < or = 0.0020) and gray matter (P < or = 0.0022). CONCLUSION: ADC histogram analysis demonstrated increased general diffusivity in the brain in NPSLE patients with acute symptoms compared with healthy normal controls. This finding suggests that in the brain parenchyma of NPSLE patients a loss of tissue integrity occurs facilitating motility of free-water protons. |
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Authors:
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Robert C Welsh; Habib Rahbar; Bradley Foerster; Majda Thurnher; Pia C Sundgren |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 26 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-04 Completed Date: 2007-10-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 541-51 Citation Subset: IM |
Copyright Information:
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(c) 2007 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Basic Radiological Sciences Division, University Hospital of Michigan, Ann Arbor, Michigan 48109-0553, USA. rcwelsh@med.umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Brain / pathology* Diffusion Diffusion Magnetic Resonance Imaging / methods Echo-Planar Imaging / methods Female Humans Lupus Erythematosus, Systemic / diagnosis*, pathology* Magnetic Resonance Imaging / methods* Male Mental Disorders / diagnosis*, pathology* Middle Aged Nervous System Diseases / diagnosis*, pathology* Protons |
| Chemical | |
Reg. No./Substance:
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0/Protons |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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