Document Detail


Brain diffusivity in patients with neuropsychiatric systemic lupus erythematosus with new acute neurological symptoms.
MedLine Citation:
PMID:  17729344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the source of significant difference in apparent diffusion coefficient (ADC) between patients with acute symptoms of neuropsychiatric (NP) systematic lupus erythematosus (SLE) (NPSLE) and normal controls. MATERIALS AND METHODS: Diffusion-weighted echo-planar imaging was performed on 1.5-T scanners in 17 female and four male NPSLE patients with acute neurological symptoms (23-76 years, mean = 42.7 years), and in 21 aged-matched healthy controls (16 female, five male, 26-63 years, mean = 41.1 years). ADC histograms were calculated for whole brain, gray matter tissue, and white matter tissue. RESULTS: Of the 17 NPSLE patients, 13 (72%) had abnormal findings on MR imaging. The NPSLE patients had a mean ADC value of (1105.1 +/- 23.6) x 10(-6) mm(2)/second and the control had a mean ADC value of (1012.5 +/- 9.4) x 10(-6) mm(2)/second (P < or = 0.0012). Significant differences were also found in white matter (P < or = 0.0020) and gray matter (P < or = 0.0022). CONCLUSION: ADC histogram analysis demonstrated increased general diffusivity in the brain in NPSLE patients with acute symptoms compared with healthy normal controls. This finding suggests that in the brain parenchyma of NPSLE patients a loss of tissue integrity occurs facilitating motility of free-water protons.
Authors:
Robert C Welsh; Habib Rahbar; Bradley Foerster; Majda Thurnher; Pia C Sundgren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  26     ISSN:  1053-1807     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-04     Completed Date:  2007-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  541-51     Citation Subset:  IM    
Copyright Information:
(c) 2007 Wiley-Liss, Inc.
Affiliation:
Department of Radiology, Basic Radiological Sciences Division, University Hospital of Michigan, Ann Arbor, Michigan 48109-0553, USA. rcwelsh@med.umich.edu
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adult
Brain / pathology*
Diffusion
Diffusion Magnetic Resonance Imaging / methods
Echo-Planar Imaging / methods
Female
Humans
Lupus Erythematosus, Systemic / diagnosis*,  pathology*
Magnetic Resonance Imaging / methods*
Male
Mental Disorders / diagnosis*,  pathology*
Middle Aged
Nervous System Diseases / diagnosis*,  pathology*
Protons
Chemical
Reg. No./Substance:
0/Protons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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