Document Detail


Brain derived neurotrophic factor circulating levels in patients undergoing IVF.
MedLine Citation:
PMID:  17721815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The aim of the study was to measure circulating BDNF levels, a neurotrophin recently identified in the ovary, in parallel with estradiol, to verify if assessing this factor could add any predictive value to the outcome of in vitro fertilization.
METHODS: Blood sampling for BDNF and estradiol was performed in 23 subjects undergoing IVF on day 1 (D1), day 8 (D8), day of HCG administration (DHCG) and day of oocyte retrieval.(DOR).
RESULTS: There was a positive correlation between BDNF and estradiol throughout the stimulation cycle in all subjects. In both pregnant and nonpregnant patients, the values of BDNF grew significantly only between D8 and DHCG and remained constant until DOR. Between-group comparisons showed no statistically significant differences in both BDNF and estradiol values throughout the IVF cycle.
CONCLUSION: Although BDNF plasma concentrations are not seemingly predictive of IVF outcome, this neurotrophin is highly correlated to estradiol levels and seems to be an important factor especially in the periovulatory period.
Authors:
P Monteleone; P G Artini; G Simi; V Cela; E Casarosa; S Begliuomini; F Ninni; N Pluchino; M Luisi; A R Genazzani
Related Documents :
15819965 - Ovum pick-up in cycling and lactating postpartum swamp buffaloes (bubalis bubalis).
2498795 - Gonadotropin and estradiol levels during ovarian stimulation in women treated with leup...
2522795 - Suppression of gonadotrophin secretion does not reverse premature ovarian failure.
8750575 - Human follicular fluid levels of endothelins in relation to oocyte maturity status.
19158425 - Ascorbic acid and rates of cognitive decline in alzheimer's disease.
8227645 - Interactions of high milk yield and reproductive performance in dairy cows.
Publication Detail:
Type:  Journal Article     Date:  2007-08-25
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  24     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-01-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  477-80     Citation Subset:  IM    
Affiliation:
Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56126 Pisa, Italy. patrizia.monteleone@gmail.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Brain-Derived Neurotrophic Factor / blood*
Estradiol / blood
Female
Fertilization in Vitro*
Humans
Pregnancy
Pregnancy Outcome
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 50-28-2/Estradiol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Complete sequence of a subgroup 3.4 strain of classical swine fever virus from Taiwan.
Next Document:  Intramuscular route of progesterone administration increases pregnancy rates during non-downregulate...