Document Detail

Brain derived neurotrophic factor circulating levels in patients undergoing IVF.
MedLine Citation:
PMID:  17721815     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of the study was to measure circulating BDNF levels, a neurotrophin recently identified in the ovary, in parallel with estradiol, to verify if assessing this factor could add any predictive value to the outcome of in vitro fertilization.
METHODS: Blood sampling for BDNF and estradiol was performed in 23 subjects undergoing IVF on day 1 (D1), day 8 (D8), day of HCG administration (DHCG) and day of oocyte retrieval.(DOR).
RESULTS: There was a positive correlation between BDNF and estradiol throughout the stimulation cycle in all subjects. In both pregnant and nonpregnant patients, the values of BDNF grew significantly only between D8 and DHCG and remained constant until DOR. Between-group comparisons showed no statistically significant differences in both BDNF and estradiol values throughout the IVF cycle.
CONCLUSION: Although BDNF plasma concentrations are not seemingly predictive of IVF outcome, this neurotrophin is highly correlated to estradiol levels and seems to be an important factor especially in the periovulatory period.
P Monteleone; P G Artini; G Simi; V Cela; E Casarosa; S Begliuomini; F Ninni; N Pluchino; M Luisi; A R Genazzani
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Publication Detail:
Type:  Journal Article     Date:  2007-08-25
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  24     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-01-14     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  477-80     Citation Subset:  IM    
Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
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MeSH Terms
Brain-Derived Neurotrophic Factor / blood*
Estradiol / blood
Fertilization in Vitro*
Pregnancy Outcome
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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