| Brain death impairs coronary endothelial function. | |
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MedLine Citation:
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PMID: 12085014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To characterize the impact of brain death (BD) on endothelial dysfunction after cardiac transplantation we investigated coronary circulation and vasomotor function in a canine model. METHODS: Left ventricular pressure-volume data (conductance catheter) and coronary blood flow (CBF) were monitored continuously. Endothelium-dependent vasodilatation after acetylcholine and endothelium-independent vasodilation after sodium nitroprusside were assessed before and 3 hr after BD induction (inflation of a subdural balloon). RESULTS: BD led to an initial hyperdynamic reaction with significant (P<0.05) increase of CBF. After 3 hr, CBF decreased significantly (P<0.05). Although before BD, application of acetylcholine led to a monophasic vasodilatative response, after BD a short mild vasodilatation was followed by a longer vasoconstriction. Endothelium-independent vasodilatation remained unchanged. CONCLUSIONS: BD affects coronary circulation by two means: (1) impairment of CBF to decrease in parallel in afterload with consecutive hemodynamic deterioration and (2) severe endothelial dysfunction that may be a contributing factor to posttransplant outcome. |
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Authors:
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Gabor Szabo; Volker Buhmann; Susanne Bahrle; Christian F Vahl; Siegfried Hagl |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Transplantation Volume: 73 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-26 Completed Date: 2002-07-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: United States |
Other Details:
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Languages: eng Pagination: 1846-8 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, University of Heidelberg, Im Neueneheimer Feld 110, 69120 Heidelberg, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Brain Death / physiopathology* Coronary Circulation / drug effects, physiology Coronary Vessels / physiopathology* Dogs Endothelium, Vascular / physiopathology* Heart Transplantation* Hemodynamics / physiology Nitroprusside / pharmacology Postoperative Complications / physiopathology Vasodilation / drug effects Vasodilator Agents / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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