Document Detail

Brain death during pregnancy: tocolytic therapy and aggressive maternal support on behalf of the fetus.
MedLine Citation:
PMID:  9263566     Owner:  NLM     Status:  MEDLINE    
We report a case of maternal brain death at 25 weeks gestation in which aggressive maternal hemodynamic, respiratory, and metabolic support and tocolytic drug therapy resulted in prolongation of pregnancy for 25 days. The indication for delivery was torulopsis giabrata amnionitis, which may have occurred due to transmembrane or transplacental route. The baby was treated for fungal sepsis, and did well. Premature labor may occur spontaneously after maternal brain death, and may be precipitated by infection or by maternal drug therapy. The myriad of hemodynamic and endocrine issues associated with maternal brain death complicate the choice of tocolytic drugs, but this case illustrates that uterine activity can be successfully blocked, potentially diminishing risks to the newborn, following the tragedy of maternal brain death during pregnancy.
V A Catanzarite; D C Willms; K E Holdy; S E Gardner; D M Ludwig; L M Cousins
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  14     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-09-30     Completed Date:  1997-09-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  431-4     Citation Subset:  IM    
Maternal-Fetal Medicine, Sharp Memorial Hospital, San Diego, California, USA.
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MeSH Terms
Amphotericin B / therapeutic use
Brain Death*
Candidiasis / diagnosis,  therapy
Cerebral Hemorrhage / diagnosis,  therapy*
Disease-Free Survival
Fatal Outcome
Fungemia / diagnosis,  therapy
Infant, Newborn
Infant, Newborn, Diseases / diagnosis,  therapy*
Obstetric Labor, Premature / etiology,  prevention & control*
Pneumonia / diagnosis,  therapy*
Pregnancy Complications, Cardiovascular / diagnosis,  therapy*
Pregnancy Outcome
Pregnancy Trimester, Second
Tocolysis / methods*
Reg. No./Substance:
1397-89-3/Amphotericin B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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