| Brain damage in preterm newborns: biological response modification as a strategy to reduce disabilities. | |
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MedLine Citation:
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PMID: 10753239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Substances that promote the growth and maturation of oligodendrocytes and their precursors might protect against white matter injury. We suggest that neuroprotection can also be provided by such modulators of fetal and neonatal inflammatory responses as antiinflammatory cytokines, cytokine-binding proteins, and cytokine-receptor blockers. We briefly describe inflammatory responses in the fetus and newborn and show how they might contribute to brain damage. We conclude with the possibility that so-called biological response modifiers, which are drugs that modulate these inflammatory responses, might reduce the risk of brain damage and disabilities. |
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Authors:
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O Dammann; A Leviton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: The Journal of pediatrics Volume: 136 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-05-03 Completed Date: 2000-05-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 433-8 Citation Subset: AIM; IM |
Affiliation:
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Neuroepidemiology Unit, Department of Neurology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain Damage, Chronic
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etiology,
prevention & control* Humans Immunologic Factors / therapeutic use* Infant, Newborn Infant, Premature Infant, Premature, Diseases / drug therapy*, etiology Mentally Disabled Persons* |
| Chemical | |
Reg. No./Substance:
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0/Immunologic Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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