Document Detail

Brain damage in preterm newborns: might enhancement of developmentally regulated endogenous protection open a door for prevention?
MedLine Citation:
PMID:  10469783     Owner:  NLM     Status:  MEDLINE    
We present a two-component model of brain white matter damage in preterm neonates. The insult component comprises infection and hypoxia-ischemia, which are both associated with inflammation-related abnormalities in the white matter. The developmental component comprises at least three factors, ie, immaturity of the ependymal/endothelial, oligodendroglial, and endogenous protection systems. All three factors are likely contributors to an increased vulnerability of the preterm newborn's white matter. In this article, we focus on recent developments in oligodendrocyte biology that support the view of certain cytokines and growth factors as oligotrophins based on their capability to enhance oligodendrocyte development or survival. We suggest that research into networks of developmentally regulated endogenous protectors (such as oligotrophins) is necessary to broaden our perspectives in brain injury prevention in preterm newborns.
O Dammann; A Leviton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Pediatrics     Volume:  104     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-50     Citation Subset:  AIM; IM    
Neuroepidemiology Unit, Department of Neurology, Children's Hospital, Boston, Massachusetts 02115, USA.
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MeSH Terms
Brain Damage, Chronic / prevention & control*
Cytokines / physiology
Growth Substances / physiology
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / prevention & control*
Models, Biological
Oligodendroglia / physiology
Grant Support
Reg. No./Substance:
0/Cytokines; 0/Growth Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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