Document Detail

Brain damage in the premature infant. Early lesions and new aspects of sequelae.
MedLine Citation:
PMID:  3759408     Owner:  NLM     Status:  MEDLINE    
In spite of a significant decrease of the mortality and morbidity of neonates, cerebral damage in the premature infant remains the major concern for the neonatologist. Intraventricular hemorrhage (IVH) and necrosis of the white matter (leukomalacia) are the two main lesions. Early morphological aspects have been known for many years, but the use of computerized tomography (CT scan) and ultrasonography (US) through the anterior fontanelle have led to renewed interest and the general recognition of IVH. Localization, extent and frequency of the lesions can readily be established. However the early diagnosis of leukomalacia is still uncertain. Long survival, with mechanical ventilation of severely ill infants, has made it possible to follow the natural history of the lesions and has modified the relative frequency of their occurrence. Posthemorrhagic hydrocephalus, sclerosis of the centrum semiovale and multicystic encephalopathy are now commonly found at autopsy of infants who have survived for several weeks.
J C Larroche; O Bethmann; M Baudoin; M Couchard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  Suppl 5     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1986 Apr 
Date Detail:
Created Date:  1986-11-03     Completed Date:  1986-11-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  43-52     Citation Subset:  IM    
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MeSH Terms
Brain / pathology*
Brain Damage, Chronic / diagnosis*,  epidemiology,  pathology
Cerebral Hemorrhage / diagnosis*,  pathology
Encephalomalacia / diagnosis*,  pathology
Infant, Newborn
Infant, Premature, Diseases / diagnosis*,  epidemiology,  pathology

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