| Brain corticosteroid receptors and regulation of arterial blood pressure. | |
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MedLine Citation:
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PMID: 2561139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single intracerebroventricular injection of 10 ng of the mineralocorticoid aldosterone in normotensive male Wistar rats induced a transient increase in blood pressure. Corticosterone produced this response only at a 100-fold higher dose. In contrast, a decrease in systolic blood pressure occurred following the intracerebroventricular administration of a selective glucocorticoid agonist (Ru 28362; 10 ng). The intracerebroventricular administration in normotensive and adrenalectomized, corticosterone-replaced, male rats of an antimineralocorticoid (Ru 28318; 10 ng) decreased systolic blood pressure, while an antiglucocorticoid (Ru 38486; 10 ng) caused an increase. These data suggest that adrenal steroids affect central mechanisms underlying cardiovascular regulation by binding to central mineralo- and glucocorticoid receptors. |
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Authors:
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D T van den Berg; E R de Kloet; H H van Dijken; W de Jong |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of hypertension. Supplement : official journal of the International Society of Hypertension Volume: 7 ISSN: 0952-1178 ISO Abbreviation: J Hypertens Suppl Publication Date: 1989 Dec |
Date Detail:
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Created Date: 1990-05-11 Completed Date: 1990-05-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8501422 Medline TA: J Hypertens Suppl Country: ENGLAND |
Other Details:
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Languages: eng Pagination: S202-3 Citation Subset: IM |
Affiliation:
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Rudolf Magnus Institute of Pharmacology, University of Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects, physiology* Brain / drug effects, physiology* Dose-Response Relationship, Drug Homeostasis / drug effects, physiology Male Mineralocorticoids / physiology Rats Rats, Inbred Strains Receptors, Glucocorticoid / drug effects, physiology* Receptors, Mineralocorticoid Receptors, Steroid / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Mineralocorticoids; 0/Receptors, Glucocorticoid; 0/Receptors, Mineralocorticoid; 0/Receptors, Steroid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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