Document Detail

Brain cortex tissue Ca, Mg, Fe, Na, and K following resuscitation from cardiac arrest in dogs.
MedLine Citation:
PMID:  3814277     Owner:  NLM     Status:  MEDLINE    
Recent evidence suggests that ultimate neurologic injury following cardiac arrest and resuscitation may be largely determined by biochemical events occurring during reperfusion. To test this hypothesis and further characterize the time course of some of these events, we examined tissue samples from the parietal cortex for their total content of calcium (Ca), magnesium (Mg), iron (Fe), sodium (Na), and potassium (K) after 10 minutes, two hours, four hours, and eight hours of reperfusion following a 15-minute cardiac arrest in dogs. After 10 minutes of reperfusion, there were relatively small, but significant, increases in the total tissue content of Ca and Na, as compared to nonischemic controls. All values had returned to normal at two hours and remained normal at four hours of reperfusion. However, at eight hours of reperfusion, Ca and Na content approximately doubled and K content was reduced by half. There were no significant changes at any time in the tissue content of Fe or Mg. We conclude that with between four and eight hours of reperfusion following a 15-minute cardiac arrest, a major defect occurs in many cells of the cortex with respect to their ability to control ionic balances of Ca, Na, and K. This might be explained either by failure of the energy-dependent ionic pumps or by more generalized damage to the membrane permeability barrier by a process such as lipid peroxidation.
T J Hoehner; A M Garritano; R A Dilorenzo; B J O'Neil; K Kumar; J Koehler; N R Nayini; R R Huang; G S Krause; S D Aust
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  5     ISSN:  0735-6757     ISO Abbreviation:  Am J Emerg Med     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-04-01     Completed Date:  1987-04-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Heart Arrest / therapy*
Iron / metabolism
Magnesium / metabolism
Parietal Lobe / metabolism*
Potassium / metabolism
Sodium / metabolism
Reg. No./Substance:
7439-89-6/Iron; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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