| Brain concentrations of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients. | |
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MedLine Citation:
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PMID: 729606 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-Epoxide) in the temporal lobe were measured in five epileptic patients undergoing unilateral temporal lobectomy. The patients had been under CBZ treatment from 6 months to 6 years and all were in steady state at the time of operation. The brain tissue concentration of CBZ in all patients was higher than the plasma concentration; the brain/plasma ratio ranged from 1.4--1.6. Brain/plasma ratios of CBZ-Epoxide ranged from 0.6--1.5. The ratio for CBZ was similar in patients treated with CBZ alone or in combination with other anticonvulsants, but for the CBZ-Epoxide a higher ratio was found in patients on combined treatment. The results may mean that other antiepileptic drugs, too, can influence the brain concentration of an active metabolite, which could have a bearing on the enhanced therapeutic effect often seen on combining CBZ treatment with other antiepileptic drugs. |
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Authors:
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M L Friis; J Christiansen; E F Hvidberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 14 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1978 Nov |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 47-51 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / metabolism* Carbamazepine / blood, metabolism* Child Epilepsy / metabolism* Epoxy Compounds / metabolism Female Humans Male Phenobarbital / metabolism Phenytoin / metabolism Primidone / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Epoxy Compounds; 125-33-7/Primidone; 298-46-4/Carbamazepine; 50-06-6/Phenobarbital; 57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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