Document Detail

Brain computed tomographic scan findings in acute opium overdose patients.
MedLine Citation:
PMID:  22867819     Owner:  NLM     Status:  MEDLINE    
AIM: Early radiologic evaluations including noncontrast computed tomographic (CT) scan of the brain have been reported to be useful in the diagnosis and management of the intoxicated patients. Changes in the brain CT scan of the acute opium overdose patients have little been studied to date. This study aimed to evaluate changes of the brain CT scans in the acute opium overdose patients.
METHODS: In this retrospective study, medical records of all acute opium overdose patients hospitalized in Loghman-Hakim Poison Hospital in Tehran, Iran, between September 2009 and September 2010 were identified. Those who had undergone noncontrast brain CT within the first 24 hours of hospital presentation were included. Patients with any underlying disease, head trauma, underlying central nervous system disease, epilepsy, and multidrug ingestion were excluded. The patients' demographic information, vital signs, and laboratory data at presentation were extracted and recorded. The data were analyzed using SPSS software version 17 (SPSS, Chicago, IL).
RESULTS: A total of 71 patients were included. Fifty-eight patients (80.5%) survived, and 10 (13.8%) died. Fourteen cases (19.7%) had abnormal CT findings including 8 cases of generalized cerebral edema and 6 cases of infarction/ischemia. There were no statistically significant differences between the patients with and without abnormal CT scan findings with respect to age, sex, systolic and/or diastolic blood pressures, pulse rate, respiratory rate, occurrence of seizures, pH, Pco(2), HCO(3)(-), blood sodium level, and blood glucose level (all P values were > .05). However, a statistically significant difference was found between these patients in terms of outcome (P = .007).
CONCLUSION: Abnormal brain CT findings are detected in about 20% of the acute opium overdose patients who are ill enough to warrant performance of the brain CT scan and associate with a poor prognosis in this group of the patients.
Farkhondeh Jamshidi; Babak Sadighi; Kamran Aghakhani; Hossein Sanaei-Zadeh; Mohammadali Emamhadi; Nasim Zamani
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Publication Detail:
Type:  Journal Article     Date:  2012-08-03
Journal Detail:
Title:  The American journal of emergency medicine     Volume:  31     ISSN:  1532-8171     ISO Abbreviation:  Am J Emerg Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-03-14     Revised Date:  2013-07-08    
Medline Journal Info:
Nlm Unique ID:  8309942     Medline TA:  Am J Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
Department of Forensic Medicine and Toxicology, Tehran University of Medical Sciences, Hazrat Rasoul Akram Hospital, Tehran, Iran.
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MeSH Terms
Aged, 80 and over
Brain Diseases / chemically induced*,  epidemiology,  radiography*
Chi-Square Distribution
Child, Preschool
Drug Overdose / epidemiology,  radiography*
Iran / epidemiology
Middle Aged
Opioid-Related Disorders / epidemiology,  radiography*
Retrospective Studies
Statistics, Nonparametric
Tomography, X-Ray Computed / methods*
Comment In:
Am J Emerg Med. 2013 May;31(5):880-1   [PMID:  23481160 ]
Am J Emerg Med. 2013 May;31(5):879-80   [PMID:  23453363 ]

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