Document Detail


Brain circuits regulating energy homeostasis.
MedLine Citation:
PMID:  18514925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent years have seen an impetus in the study for central mechanisms regulating energy balance, and caloric intake possibly as a response to the obesity pandemic. This renewed interest as well as drastic improvements in the tools that are now currently available to neuroscientists, has yielded a great deal of insight into the mechanisms by which the brain regulates metabolic function, and volitional aspects of feeding in response to metabolic signals like leptin, insulin and ghrelin. Among these mechanisms are the complex intracellular signals elicited by these hormones in neurons. Moreover, these signals produce and modulate the metabolism of the cell at the level of the mitochondria. Finally, these signals promote plastic changes that alter the synaptic circuitry in a number of circuits and ultimately affect cellular, physiological and behavioral responses in defense of energy homeostasis. These mechanisms are surveyed in this review.
Authors:
Alfonso Abizaid; Tamas L Horvath
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-03-25
Journal Detail:
Title:  Regulatory peptides     Volume:  149     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-11-18     Revised Date:  2010-12-03    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3-10     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, USA. alfonso_abizaid@carleton.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*,  physiology*
Energy Metabolism / physiology*
Ghrelin / metabolism,  physiology
Homeostasis / physiology*
Humans
Hypothalamus / metabolism,  physiology
Insulin / metabolism,  physiology
Leptin / metabolism,  physiology
Mesencephalon / metabolism,  physiology
Models, Biological
Grant Support
ID/Acronym/Agency:
R01 DK060711-01A1/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Leptin; 11061-68-0/Insulin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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