Document Detail

Brain cell alterations suggesting premature aging induced by dietary deficiency of vitamin B6 and/or copper.
MedLine Citation:
PMID:  6837489     Owner:  NLM     Status:  MEDLINE    
Weanling albino rats were fed semisynthetic diets deficient or sufficient in vitamin B6 or copper, or both, for 2 or 3 months. Brains were examined by light and electron microscopy after Golgi impregnation or conventional tissue processing for electron microscopy. Golgi impregnation revealed that some pyramidal cells of the cerebral cortex, particularly in layers III and V, showed partial to nearly complete dendritic loss. This occurred in all deficient groups but was most typical of deficiency of vitamin B6. Swelling in dendrites or perikarya was more typical of copper deficiency. Ultrastructural observation revealed large vacuoles in cellular processes of the cerebral cortex in deficient groups. The hippocampus of copper-deficient rats contained dark, apparently degenerating processes while axonal swellings were seen in vitamin B6 deficiency. These abnormalities are discussed as evidence for accelerated aging of neurons related to poor nutritional status.
E J Root; J B Longenecker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  37     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-05     Completed Date:  1983-05-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-52     Citation Subset:  AIM; IM    
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MeSH Terms
Aging / drug effects*
Brain / physiopathology,  ultrastructure*
Cerebral Cortex / ultrastructure
Copper / administration & dosage,  deficiency*
Golgi Apparatus
Hippocampus / ultrastructure
Pyridoxine / administration & dosage
Vitamin B 6 Deficiency / pathology*
Reg. No./Substance:
65-23-6/Pyridoxine; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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