| Brain blood flow and velocity: correlations between magnetic resonance imaging and transcranial Doppler sonography. | |
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MedLine Citation:
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PMID: 20587424 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Because transcranial Doppler sonography (TCD) is unable to measure arterial diameter, it remains unproven whether the changes in cerebral blood velocity it measures are representative of changes in cerebral blood flow (CBF). Our study was designed to compare velocity changes with flow changes measured by two magnetic resonance imaging (MRI) techniques, perfusion MRI and arterial spin labeling (ASL), using flavanol-rich cocoa to induce CBF changes in healthy volunteers. METHODS: We enrolled 20 healthy volunteers aged 62 to 80 years (mean, 73 years). Each was studied at baseline and after drinking standardized servings of cocoa for 7 to 14 days. RESULTS: Changes in middle cerebral artery (MCA) flow by TCD were significantly correlated with changes in perfusion assessed by gadolinium-enhanced MRI (r = 0.63; P < .03). Measurements with ASL showed a stronger correlation with borderline significance. CONCLUSIONS: Changes in flow velocity in the MCA associated with drinking cocoa were highly correlated with changes in CBF measured by the two MRI techniques using the tracer gadolinium and ASL. These results validate Doppler measurements of CBF velocity as representative assessments of CBF. |
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Authors:
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Farzaneh A Sorond; Norman K Hollenberg; Lawrence P Panych; Naomi D L Fisher |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine Volume: 29 ISSN: 1550-9613 ISO Abbreviation: J Ultrasound Med Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-30 Completed Date: 2010-12-02 Revised Date: 2011-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8211547 Medline TA: J Ultrasound Med Country: United States |
Other Details:
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Languages: eng Pagination: 1017-22 Citation Subset: IM |
Affiliation:
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Department of Neurology, Stroke Division, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02117, USA. fsorond@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Blood Flow Velocity Cerebrovascular Circulation* Humans Magnetic Resonance Angiography* Middle Aged Regional Blood Flow Ultrasonography, Doppler, Transcranial* |
| Grant Support | |
ID/Acronym/Agency:
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K23 AG030967-02/AG/NIA NIH HHS; K23-AG030967/AG/NIA NIH HHS; R01 HL086907/HL/NHLBI NIH HHS; R01 HL089570-03/HL/NHLBI NIH HHS; R01 HL089570-04/HL/NHLBI NIH HHS; R03 AG023896/AG/NIA NIH HHS |
| Comments/Corrections | |
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