| Brain blood flow in Andean and Himalayan high-altitude populations: evidence of different traits for the same environmental constraint. | |
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MedLine Citation:
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PMID: 20736959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Humans have populated the Tibetan plateau much longer than the Andean Altiplano. It is thought that the difference in length of occupation of these altitudes has led to different responses to the stress of hypoxia. As such, Andean populations have higher hematocrit levels than Himalayans. In contrast, Himalayans have increased circulation to certain organ systems to meet tissue oxygen demand. In this study, we hypothesize that cerebral blood flow (CBF) is higher in Himalayans than in Andeans. Using a MEDLINE and EMBASE search, we included 10 studies that investigated CBF in Andeans and Himalayans between 3,658 and 4,330 m altitude. The CBF values were corrected for differences in hematocrit and arterial oxygen saturation. The data of these studies show a mean hematocrit of 50% in Himalayans and 54.1% in Andeans. Arterial oxygen saturation was 86.9% in Andeans and 88.4% in Himalayans. The CBF in Himalayans was slightly elevated compared with sea-level subjects, and was 24% higher compared with Andeans. After correction for hematorit and arterial oxygen saturation, CBF was ∼20% higher in Himalayans compared with Andeans. Altered brain metabolism in Andeans, and/or increased nitric oxide availability in Himalayans may have a role to explain this difference in brain blood flow. |
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Authors:
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Gerard F A Jansen; Buddha Basnyat |
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Publication Detail:
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Type: Journal Article Date: 2010-08-25 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 31 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-03-17 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 706-14 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands. g.f.jansen@amc.uva.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Altitude* Blood Flow Velocity / physiology Bolivia Brain Chemistry / physiology Cerebrovascular Circulation / genetics*, physiology* Deuterium Oxide / diagnostic use Environment* Hematocrit Humans Middle Cerebral Artery / physiology Nepal Nitric Oxide / metabolism Oxygen / blood Oxygen Consumption / physiology Peru Population Ultrasonography, Doppler, Transcranial |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide; 7782-44-7/Oxygen; 7789-20-0/Deuterium Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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