Document Detail

Brain alkaline intracellular pH after neonatal encephalopathy.
MedLine Citation:
PMID:  12447926     Owner:  NLM     Status:  MEDLINE    
Experimental studies demonstrate an alkaline shift in brain intracellular pH (pH(i)) after hypoxia-ischemia (HI). In infants with neonatal encephalopathy after HI, our aims were to assess (1) brain pH(i) during the first 2 weeks after birth in infants categorized according to magnetic resonance imaging (MRI) during the first 2 weeks after birth and at more than 3 months of age, and neurodevelopmental outcome at 1 year; (2) the relationship between brain pH(i) and lactate/creatine; and (3) duration of alkaline brain pH(i). Seventy-eight term infants with neonatal encephalopathy were studied using MR techniques. One hundred and fifty-one studies were performed throughout the first year including 56 studies of 50 infants during the first 2 weeks after birth. pH(i) was calculated using phosphorus-31 MR spectroscopy and lactate/creatine was measured using proton MRS. The mean (standard deviation [SD]) brain pH(i) during the first 2 weeks after birth in infants with severely abnormal versus normal MRI was 7.24 (SD, 0.17) versus 7.04 (SD, 0.05; p < 0.001); in infants who subsequently developed cerebral atrophy versus those who did not: 7.23 (SD, 0.17) versus 7.06 (SD, 0.06; p < 0.05); in infants who died or had a severe neurodevelopmental impairment versus normal outcome: 7.28 (SD, 0.15) versus 7.11 (SD, 0.09; p < 0.05). Brain alkalosis was associated with increased brain lactate/creatine (p < 0.001). pH(i) remained more alkaline in the severe outcome group up to 20 weeks after birth (p < 0.05).
Nicola J Robertson; Frances M Cowan; I Jane Cox; A David Edwards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of neurology     Volume:  52     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-26     Completed Date:  2002-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  732-42     Citation Subset:  IM    
Department of Paediatrics, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Science, Technology and Medicine, Hammersmith Hospital Campus, DuCane Road, LondonW12 0NN, UK.
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MeSH Terms
Alkalosis / metabolism*
Analysis of Variance
Brain / metabolism*,  pathology
Brain Injuries / metabolism*,  pathology
Creatine / analysis,  metabolism*
Follow-Up Studies
Hydrogen-Ion Concentration
Infant, Newborn
Intracellular Fluid / metabolism*
Lactic Acid / analysis,  metabolism*
Logistic Models
Magnetic Resonance Imaging / methods
Prospective Studies
Reg. No./Substance:
50-21-5/Lactic Acid; 57-00-1/Creatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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