| Brain alkaline intracellular pH after neonatal encephalopathy. | |
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MedLine Citation:
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PMID: 12447926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Experimental studies demonstrate an alkaline shift in brain intracellular pH (pH(i)) after hypoxia-ischemia (HI). In infants with neonatal encephalopathy after HI, our aims were to assess (1) brain pH(i) during the first 2 weeks after birth in infants categorized according to magnetic resonance imaging (MRI) during the first 2 weeks after birth and at more than 3 months of age, and neurodevelopmental outcome at 1 year; (2) the relationship between brain pH(i) and lactate/creatine; and (3) duration of alkaline brain pH(i). Seventy-eight term infants with neonatal encephalopathy were studied using MR techniques. One hundred and fifty-one studies were performed throughout the first year including 56 studies of 50 infants during the first 2 weeks after birth. pH(i) was calculated using phosphorus-31 MR spectroscopy and lactate/creatine was measured using proton MRS. The mean (standard deviation [SD]) brain pH(i) during the first 2 weeks after birth in infants with severely abnormal versus normal MRI was 7.24 (SD, 0.17) versus 7.04 (SD, 0.05; p < 0.001); in infants who subsequently developed cerebral atrophy versus those who did not: 7.23 (SD, 0.17) versus 7.06 (SD, 0.06; p < 0.05); in infants who died or had a severe neurodevelopmental impairment versus normal outcome: 7.28 (SD, 0.15) versus 7.11 (SD, 0.09; p < 0.05). Brain alkalosis was associated with increased brain lactate/creatine (p < 0.001). pH(i) remained more alkaline in the severe outcome group up to 20 weeks after birth (p < 0.05). |
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Authors:
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Nicola J Robertson; Frances M Cowan; I Jane Cox; A David Edwards |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 52 ISSN: 0364-5134 ISO Abbreviation: Ann. Neurol. Publication Date: 2002 Dec |
Date Detail:
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Created Date: 2002-11-26 Completed Date: 2002-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 732-42 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Division of Paediatrics, Obstetrics and Gynaecology, Imperial College School of Science, Technology and Medicine, Hammersmith Hospital Campus, DuCane Road, LondonW12 0NN, UK. n.robertson@ic.ac.uk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkalosis
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metabolism* Analysis of Variance Brain / metabolism*, pathology Brain Injuries / metabolism*, pathology Creatine / analysis, metabolism* Follow-Up Studies Humans Hydrogen-Ion Concentration Infant Infant, Newborn Intracellular Fluid / metabolism* Lactic Acid / analysis, metabolism* Logistic Models Magnetic Resonance Imaging / methods Prospective Studies |
| Chemical | |
Reg. No./Substance:
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50-21-5/Lactic Acid; 57-00-1/Creatine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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