Document Detail

Brain activity in cigarette smokers performing a working memory task: effect of smoking abstinence.
MedLine Citation:
PMID:  16038685     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: When nicotine-dependent human subjects abstain from cigarette smoking, they exhibit deficits in working memory. An understanding of the neural substrates of such impairments may help to understand how nicotine affects cognition. Our aim, therefore, was to identify abnormalities in the circuitry that mediates working memory in nicotine-dependent subjects after they initiate abstinence from smoking.
METHODS: We used blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to study eight smokers while they performed a letter version of the N-Back working memory task under satiety (< or = 1.5 hours abstinence) and abstinence (> or = 14 hours abstinence) conditions.
RESULTS: Task-related activity in the left dorsal lateral prefrontal cortex (DLPFC) showed a significant interaction between test session (satiety, abstinence) and task load (1-back, 2-back, and 3-back). This interaction reflected the fact that task-related activity in the satiety condition was relatively low during performance of the 1-back task but greater at the more difficult task levels, whereas task-related activity in the abstinence condition was relatively high at the 1-back level and did not increase at the more difficult task levels.
CONCLUSIONS: We conclude that neural processing related to working memory in the left DLPFC is less efficient during acute abstinence from smoking than at smoking satiety.
Jiansong Xu; Adrianna Mendrek; Mark S Cohen; John Monterosso; Paul Rodriguez; Sara L Simon; Arthur Brody; Murray Jarvik; Catherine P Domier; Richard Olmstead; Monique Ernst; Edythe D London
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  58     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-25     Completed Date:  2005-10-20     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  IM    
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MeSH Terms
Brain Mapping*
Magnetic Resonance Imaging
Memory, Short-Term / drug effects,  physiology*
Middle Aged
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology
Prefrontal Cortex / drug effects,  physiology*
Reaction Time / drug effects,  physiology
Smoking / psychology*
Smoking Cessation / psychology
Tobacco Use Disorder / physiopathology,  psychology
Grant Support
DA13637/DA/NIDA NIH HHS; M01 RR 00865/RR/NCRR NIH HHS; R01 DA014093.03/DA/NIDA NIH HHS; R01 DA015059/DA/NIDA NIH HHS; R01 DA015059/DA/NIDA NIH HHS; R01 DA015059-04/DA/NIDA NIH HHS; R01 DA020872/DA/NIDA NIH HHS; R01 DA020872-01/DA/NIDA NIH HHS; R12169//PHS HHS; R21 DA 13627/DA/NIDA NIH HHS; RR08655/RR/NCRR NIH HHS
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine
Erratum In:
Biol Psychiatry. 2006 Jul 15;60(2):204

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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