Document Detail


Brain activity following esophageal acid infusion using positron emission tomography.
MedLine Citation:
PMID:  21086568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To investigate symptoms and brain activity following esophageal acid infusion.
METHODS: Fifteen healthy volunteers were recruited for the study. Hydrochloric acid (pH 1 and 2) and distilled water (pH 7) were randomly and repeatedly infused into the esophagus. The brain activity was evaluated by positron emission tomography. The severity of heartburn elicited by the infusion was rated on an auditory analog scale of 0-10.
RESULTS: The severity of heartburn following each infusion showed a step-wise increase with increasing acidity of the perfusate. The heartburn scores were significantly higher in the second pH 1 infusion compared with the first infusion. Acid and distilled water infusion induced activation of various brain areas such as the anterior insula, temporal gyrus, and anterior/posterior cingulate cortex. At pH 1 or 2, in particular, activation was observed in some emotion-related brain areas such as the more anterior part of the anterior cingulate cortex, parahippocampal gyrus, or the temporal pole. Strong activation of the orbitofrontal cortex was found by subtraction analysis of the two second pH 1 infusions, with a significant increase of heartburn symptoms.
CONCLUSION: Emotion-related brain areas were activated by esophageal acid stimulation. The orbitofrontal area might be involved in symptom processing, with esophageal sensitization induced by repeated acid stimulation.
Authors:
Shigeyuki Kobayashi; Yasuhiko Abe; Manabu Tashiro; Tomoyuki Koike; Katsunori Iijima; Akira Imatani; Shuichi Ohara; Satoshi Watanabe; Shin Fukudo; Tooru Shimosegawa
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  16     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-18     Completed Date:  2011-04-08     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5481-9     Citation Subset:  IM    
Affiliation:
Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8574, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiology*,  radionuclide imaging*
Gyrus Cinguli / physiology,  radionuclide imaging
Heartburn / chemically induced*,  epidemiology,  physiopathology
Humans
Hydrochloric Acid / adverse effects*
Hydrogen-Ion Concentration
Incidence
Male
Parahippocampal Gyrus / physiology,  radionuclide imaging
Positron-Emission Tomography*
Severity of Illness Index
Chemical
Reg. No./Substance:
7647-01-0/Hydrochloric Acid
Comments/Corrections

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