| Brain activation by disgust-inducing pictures in obsessive-compulsive disorder. | |
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MedLine Citation:
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PMID: 14512216 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is growing interest in the role of disgust in the pathogenesis of obsessive-compulsive disorder (OCD). METHODS: Eight OCD subjects with contamination preoccupations and eight gender- and age-matched healthy volunteers viewed pictures from the International Affective Picture System during functional magnetic resonance imaging scans. RESULTS: A different distribution of brain activations was found during disgust-inducing visual stimulation in several areas, most notably the insula, compared with neutral stimulation in both OCD subjects and healthy volunteers. Furthermore, whereas activation during the threat-inducing task in OCD subjects showed a pattern similar to that in healthy volunteers, the pattern of activation during the disgust-inducing task was significantly different, including greater increases in the right insula, parahippocampal region, and inferior frontal sites. CONCLUSIONS: This pilot study supports the relevance of disgust in the neurocircuitry of OCD with contamination-preoccupation symptoms; future studies looking at non-OCD individuals with high disgust ratings, non-contamination-preoccupied OCD individuals, and individuals with other anxiety disorders are needed. |
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Authors:
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Nathan A Shapira; Yijun Liu; Alex G He; Margaret M Bradley; Mary C Lessig; George A James; Dan J Stein; Peter J Lang; Wayne K Goodman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biological psychiatry Volume: 54 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-09-26 Completed Date: 2003-10-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 751-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / pathology* Brain Mapping Case-Control Studies Emotions* Female Humans Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Obsessive-Compulsive Disorder / pathology*, physiopathology* Photic Stimulation Psychiatric Status Rating Scales |
| Grant Support | |
ID/Acronym/Agency:
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MH 37757/MH/NIMH NIH HHS; MH 43975/MH/NIMH NIH HHS; P50 MH 523384/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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