Document Detail

Brain abscesses in neonates. A study of 30 cases.
MedLine Citation:
PMID:  3057126     Owner:  NLM     Status:  MEDLINE    
Since the introduction of ultrasonography and computerized tomography (CT) scanning, brain abscesses are found more frequently in cases of neonatal meningitis and septicemia, particularly when the offending pathogen is Proteus. Thirty cases of brain abscess in neonates are reported, 27 of which were caused by Proteus species infections. Twenty infants had meningitis and 13 had septicemia. Most of the abscesses were enormous, and multiple abscesses were observed in 17 cases. The frontal region was involved in 22 cases (12 unilaterally and 10 bilaterally). The ventricles were enlarged on the first CT scan in 13 cases. The abscesses were treated by aspiration and antibiotics in 25 cases, and by antibiotics alone in five. A shunt for hydrocephalus was necessary in 14 infants. Four infants died, three from the initial illness and one from a shunt complication. Sixteen children have seizures. Subsequent intelligence quotient (IQ) testing was performed in 22 children: eight (36%) have an IQ at or above 80 and eight have an IQ of less than 60. In the 17 children followed for more than 2 years, the proportion with an IQ at or above 80 fell to 24% (four cases). The absence of initial seizures, sterile cerebrospinal fluid, normal ventricles on CT scans, and early aspiration of the abscess seem to be factors portending a better prognosis in terms of epilepsy and mental sequelae.
D Renier; C Flandin; E Hirsch; J F Hirsch
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  69     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-01-10     Completed Date:  1989-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  877-82     Citation Subset:  AIM; IM    
Department of Neurosurgery, Hôpital des Enfants Malades, Paris, France.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Brain Abscess / etiology,  mortality,  therapy*
Child, Preschool
Epilepsy / complications
Hydrocephalus / complications,  psychology
Infant Mortality
Proteus Infections
Proteus mirabilis
Tomography, X-Ray Computed
Reg. No./Substance:
0/Anti-Bacterial Agents

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