Document Detail

Brain abnormalities in infants with Potter syndrome (oligohydramnios tetrad).
MedLine Citation:
PMID:  7198213     Owner:  NLM     Status:  MEDLINE    
We examined the brains of seven unrelated infants with Potter syndrome (oligohydramnios tetrad), a lethal neonatal disorder characterized by abnormal facies, lung hypoplasia, limb deformities, and classically, renal agenesis. All infants had defects of neuronal migration. The brains were small for gestational age in five of seven infants, and in four infants, the middle and inferior temporal gyri were incompletely demarcated. Cerebellar heterotopia occurred in five infants. All had abnormal hippocampi and abnormal lamination of the cerebral cortex. These neuropathologic abnormalities suggest that Potter syndrome may not be the result of a single toxic or infectious insult but may represent a polygenic inherited disorder.
M L Grunnet; J F Bale
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  31     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1571-4     Citation Subset:  AIM; IM    
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MeSH Terms
Amniotic Fluid / pathology*
Brain / abnormalities*
Face / pathology
Infant, Newborn
Kidney Diseases / complications
Urologic Diseases / complications

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