Document Detail

Brain structural variability due to aging and gender in cognitively healthy Elders: results from the Sao Paulo Ageing and Health study.
MedLine Citation:
PMID:  19661175     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Several morphometric MR imaging studies have investigated age- and sex-related cerebral volume changes in healthy human brains, most often by using samples spanning several decades of life and linear correlation methods. This study aimed to map the normal pattern of regional age-related volumetric reductions specifically in the elderly population. MATERIALS AND METHODS: One hundred thirty-two eligible individuals (67-75 years of age) were selected from a community-based sample recruited for the S??o Paulo Ageing and Health (SPAH) study, and a cross-sectional MR imaging investigation was performed concurrently with the second SPAH wave. We used voxel-based morphometry (VBM) to conduct a voxelwise search for significant linear correlations between gray matter (GM) volumes and age. In addition, region-of-interest masks were used to investigate whether the relationship between regional GM (rGM) volumes and age would be best predicted by a nonlinear model. RESULTS: VBM and region-of-interest analyses revealed selective foci of accelerated rGM loss exclusively in men, involving the temporal neocortex, prefrontal cortex, and medial temporal region. The only structure in which GM volumetric changes were best predicted by a nonlinear model was the left parahippocampal gyrus. CONCLUSIONS: The variable patterns of age-related GM loss across separate neocortical and temporolimbic regions highlight the complexity of degenerative processes that affect the healthy human brain across the life span. The detection of age-related limbic GM decrease in men supports the view that atrophy in such regions should be seen as compatible with normal aging.
P K Curiati; J H Tamashiro; P Squarzoni; F L S Duran; L C Santos; M Wajngarten; C C Leite; H Vallada; P R Menezes; M Scazufca; G F Busatto; T C T F Alves
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-06
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  30     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1850-6     Citation Subset:  IM    
Psychiatry Department, Sao Paulo University Medical School, Sao Paulo Brazil.
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MeSH Terms
Aging / pathology*
Brain / anatomy & histology,  pathology*
Brain Mapping / methods*,  standards
Cross-Sectional Studies
Magnetic Resonance Imaging / standards,  statistics & numerical data*
Nonlinear Dynamics
Predictive Value of Tests
Reference Values
Regression Analysis
Sex Characteristics
Grant Support
GR066133MA//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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