| Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. | |
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MedLine Citation:
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PMID: 21343524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In addition to cognitive dysfunction, locomotor deficits are prevalent in traumatic brain injured (TBI) patients; however, it is unclear how a concussive injury can affect spinal cord centers. Moreover, there are no current efficient treatments that can counteract the broad pathology associated with TBI. OBJECTIVE: The authors have investigated potential molecular basis for the disruptive effects of TBI on spinal cord and hippocampus and the neuroprotection of a curcumin derivative to reduce the effects of experimental TBI. METHODS: The authors performed fluid percussion injury (FPI) and then rats were exposed to dietary supplementation of the curcumin derivative (CNB-001; 500 ppm). The curry spice curcumin has protective capacity in animal models of neurodegenerative diseases, and the curcumin derivative has enhanced brain absorption and biological activity. RESULTS: The results show that FPI in rats, in addition to reducing learning ability, reduced locomotor performance. Behavioral deficits were accompanied by reductions in molecular systems important for synaptic plasticity underlying behavioral plasticity in the brain and spinal cord. The post-TBI dietary supplementation of the curcumin derivative normalized levels of BDNF, and its downstream effectors on synaptic plasticity (CREB, synapsin I) and neuronal signaling (CaMKII), as well as levels of oxidative stress-related molecules (SOD, Sir2). CONCLUSIONS: These studies define a mechanism by which TBI can compromise centers related to cognitive processing and locomotion. The findings also show the influence of the curcumin derivative on synaptic plasticity events in the brain and spinal cord and emphasize the therapeutic potential of this noninvasive dietary intervention for TBI. |
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Authors:
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Aiguo Wu; Zhe Ying; David Schubert; Fernando Gomez-Pinilla |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-22 |
Journal Detail:
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Title: Neurorehabilitation and neural repair Volume: 25 ISSN: 1552-6844 ISO Abbreviation: Neurorehabil Neural Repair Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-03-31 Completed Date: 2012-03-07 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 100892086 Medline TA: Neurorehabil Neural Repair Country: United States |
Other Details:
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Languages: eng Pagination: 332-42 Citation Subset: IM |
Affiliation:
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University of California at Los Angeles, Los Angeles, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Injuries / complications, diet therapy, drug therapy* Cognition Disorders / diet therapy, drug therapy*, etiology Curcumin / analogs & derivatives*, chemistry, pharmacology, therapeutic use Disease Models, Animal Gait Disorders, Neurologic / diet therapy, drug therapy*, etiology Male Neuroprotective Agents / chemistry, pharmacology*, therapeutic use Paresis / diet therapy, drug therapy*, etiology Pyrazoles / chemistry, pharmacology*, therapeutic use Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS056413/NS/NINDS NIH HHS; R01 NS056413-02/NS/NINDS NIH HHS; R01 NS056413-03/NS/NINDS NIH HHS; RC1 NS068473/NS/NINDS NIH HHS; RC1 NS068473-01/NS/NINDS NIH HHS; RC1 NS068473-02/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/CNB 001; 0/Neuroprotective Agents; 0/Pyrazoles; 458-37-7/Curcumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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