Document Detail


Brain SPECT findings in long-term inhalant abuse.
MedLine Citation:
PMID:  11039461     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluates brain perfusion in long-term inhalant abusers of toluene, acetone, benzene and derivatives. Ten patients in the age range 16-18 years (mean, 17.3+/-0.67 years), who had been inhalant dependent for a mean period of 48.3+/-6.2 months, but who had stopped using inhalants for 1-11 months (mean, 5.4+/-2.1 months), and ten controls (mean age, 17.3+/-0.67 years) were included in the study. Psychiatric tests, biochemical tests and Tc-99m-hexamethylpropyleneamine oxime (Tc-99m-HMPAO) brain single photon emission computed tomography (SPECT) were performed on all patients. Brain SPECT images were evaluated qualitatively and quantitatively. The mean IQ level was found to be 84 (by psychological tests). Brain SPECT showed non-homogeneous Tc-99m-HMPAO uptake and hypoperfusion areas in all patients (five left temporal, one right temporal, two left temporal plus bilateral parietooccipital, one biparietal and one left temporoparietal). Seven patients had hyperperfused foci (unifocal in five patients and multifocal in two patients). Six hyperperfused foci were in a parietal and one in a temporoparietal location. This study suggests that inhalant dependents exhibit serious abnormalities in brain SPECT images, including hypo-hyperperfusion foci and non-homogeneous uptake of the radiopharmaceutical. A further study with a larger number of patients and long-term follow-up may help to reach a more specific conclusion.
Authors:
N O Küçük; E O Kiliç; E Ibis; A Aysev; E A Gençoglu; G Aras; A Soylu; G Erbay
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  21     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-02-15     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  769-73     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Ankara University Medical School, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain / radionuclide imaging*
Humans
Intelligence Tests
Male
Neuropsychological Tests
Prisoners
Solvents
Substance-Related Disorders / radionuclide imaging*
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Solvents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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