| Brain microglial cytokines in neurogenic hypertension. | |
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MedLine Citation:
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PMID: 20547972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Accumulating evidence indicates a key role of inflammation in hypertension and cardiovascular disorders. However, the role of inflammatory processes in neurogenic hypertension remains to be determined. Thus, our objective in the present study was to test the hypothesis that activation of microglial cells and the generation of proinflammatory cytokines in the paraventricular nucleus (PVN) contribute to neurogenic hypertension. Intracerebroventricular infusion of minocycline, an anti-inflammatory antibiotic, caused a significant attenuation of mean arterial pressure, cardiac hypertrophy, and plasma norepinephrine induced by chronic angiotensin II infusion. This was associated with decreases in the numbers of activated microglia and mRNAs for interleukin (IL) 1beta, IL-6, and tumor necrosis factor-alpha, and an increase in the mRNA for IL-10 in the PVN. Overexpression of IL-10 induced by recombinant adenoassociated virus-mediated gene transfer in the PVN mimicked the antihypertensive effects of minocycline. Furthermore, acute application of a proinflammatory cytokine, IL-1beta, into the left ventricle or the PVN in normal rats resulted in a significant increase in mean arterial pressure. Collectively, this indicates that angiotensin II induced hypertension involves activation of microglia and increases in proinflammatory cytokines in the PVN. These data have significant implications on the development of innovative therapeutic strategies for the control of neurogenic hypertension. |
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Authors:
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Peng Shi; Carlos Diez-Freire; Joo Yun Jun; Yanfei Qi; Michael J Katovich; Qiuhong Li; Srinivas Sriramula; Joseph Francis; Colin Sumners; Mohan K Raizada |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-14 |
Journal Detail:
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Title: Hypertension Volume: 56 ISSN: 1524-4563 ISO Abbreviation: Hypertension Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-08-10 Revised Date: 2012-01-12 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: United States |
Other Details:
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Languages: eng Pagination: 297-303 Citation Subset: IM |
Affiliation:
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Department of Physiology and Functional Genomics, University of Florida, Gainesville, FL 32610, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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antagonists & inhibitors,
pharmacology Animals Anti-Bacterial Agents / pharmacology Blood Pressure Brain / drug effects, metabolism*, physiopathology Cytokines / blood, genetics, metabolism* Gene Transfer Techniques Heart Rate Immunohistochemistry Inflammation / physiopathology* Interleukin-10 / genetics Interleukin-1beta / genetics Interleukin-6 / genetics Male Microglia / drug effects, metabolism* Minocycline / pharmacology Prosencephalon / drug effects, metabolism, physiopathology RNA, Messenger / genetics Rats Rats, Sprague-Dawley Tumor Necrosis Factor-alpha / genetics |
| Grant Support | |
ID/Acronym/Agency:
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HL 076803/HL/NHLBI NIH HHS; HL33610/HL/NHLBI NIH HHS; R37 HL033610-25/HL/NHLBI NIH HHS; R37 HL033610-26/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cytokines; 0/Interleukin-1beta; 0/Interleukin-6; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 10118-90-8/Minocycline; 11128-99-7/Angiotensin II; 130068-27-8/Interleukin-10 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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