| Brain MRI findings in cirrhotic patients: correlation with Doppler US hepatic flow parameters. | |
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MedLine Citation:
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PMID: 15816448 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND/AIMS: To determine the relationship of basal ganglia alterations demonstrated on brain MRI and clinical presentation, evaluated with Child-Pugh score, using Color Doppler Ultrasonography parameters of portal hemodynamics in cirrhotic patients with signs of portal hypertension. METHODOLOGY: Twenty randomly selected cirrhotic patients (16 males and 4 females with a mean age of 63.6+/-8.9 years) classified according to Child-Pugh score (grade A=16 patients, grade B=4), were submitted to Color Doppler US evaluation of hepatic flow and brain MRI. The obtained flow parameters were: PVD, PVCSA, MPVF, MPVFV, HAD, MHAF, hepatic artery RI, CI and MHI. The basal ganglia signal intensity, on T1-weighted images on brain MRI was evaluated both qualitatively (normal, mild, moderate and severe) and quantitatively with the ROI method. RESULTS: Among Color Doppler parameters, only the CI exhibited a modest correlation with the Child's clinical score (p for linear trend by ANOVA <0.05). Subjective MRI grading demonstrated an excellent correlation with the qualitative assessment of signal density (Spearman p=0.95, p<0.01). When signal intensity on T1-weighted images was analyzed as a continuous variable with normal distribution and ultrasonographic parameters as possible determinants, the portal vein diameter (PVD) and consequently the cross-sectional area (PVCSA) emerged as the sole predictor of MR signal intensity (Pearson's r=0.58, p=0.01). CONCLUSIONS: Although this is a preliminary study and further research should be performed including a larger number of patients, it suggests that Color Doppler US might play a prognostic role in predicting hepatocellular dysfunction and hepatic encephalopathy. |
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Authors:
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Ek Solomou; G Terzis; I Tsota; An Kalogeropoulos; D Velissaris; M Kiriakopoulou; Ch Karatza |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hepato-gastroenterology Volume: 52 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 2005 Mar-Apr |
Date Detail:
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Created Date: 2005-04-08 Completed Date: 2005-07-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: Greece |
Other Details:
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Languages: eng Pagination: 420-4 Citation Subset: IM |
Affiliation:
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Department of Radiology, University Hospital of Patras, Rio, Greece. Solomou@med.upatras.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Basal Ganglia / pathology Brain / pathology* Female Humans Liver Circulation* Liver Cirrhosis / diagnosis*, physiopathology*, ultrasonography Magnetic Resonance Imaging* Male Middle Aged Severity of Illness Index Ultrasonography, Doppler, Color* |
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