Document Detail


Brain MRI findings in Wernicke encephalopathy.
MedLine Citation:
PMID:  24195023     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A 71-year-old woman with myelofibrosis on chemotherapy experienced an acute illness with nausea, vomiting, and diarrhea. Two weeks later, she developed an acute confusional state characterized by disorientation and fluctuating alertness with normal speech and language. Her neurologic examination demonstrated an upper motor neuron pattern of right hemiparesis. She reported double vision though ophthalmoparesis was not appreciated. Her gait was normal. While hospitalized, she developed generalized tonic-clonic seizures. Brain MRI revealed a small area of restricted diffusion of the left precentral gyrus (figure). She was diagnosed with a stroke with secondary seizures; however, as the confusional state resolved, she developed profound retrograde and anterograde amnesia. Review of the brain MRI showed high T2 signal in the medial thalamus and contrast enhancement of the mamillary bodies; a diagnosis of Wernicke-Korsakoff syndrome was entertained and she was started on thiamine replacement. The encephalopathy and hemiparesis resolved though she remains severely amnestic.
Authors:
Meredith R Wicklund; David S Knopman
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Neurology. Clinical practice     Volume:  3     ISSN:  2163-0402     ISO Abbreviation:  Neurol Clin Pract     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101577149     Medline TA:  Neurol Clin Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  363-364     Citation Subset:  -    
Affiliation:
Department of Neurology, Mayo Clinic, Rochester, MN.
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