Document Detail

Brain MR imaging in patients with hepatic cirrhosis: relationship between high intensity signal in basal ganglia on T1-weighted images and elemental concentrations in brain.
MedLine Citation:
PMID:  9272489     Owner:  NLM     Status:  MEDLINE    
In patients with hepatic cirrhosis, the globus pallidus and putamen show high intensity on T1-weighted MRI. While the causes of this high signal have been thought to include paramagnetic substances, especially manganese, no evidence for this has been presented. Autopsy in four cases of hepatic cirrhosis permitted measurement of metal concentrations in brain and histopathological examination. In three cases the globus pallidus showed high intensity on T1-weighted images. Mean manganese concentrations in globus pallidus, putamen and frontal white matter were 3.03 +/- 0.38, 2.12 +/- 0.37, and 1.38 +/- 0.24 (micrograms/g wet weight), respectively, being approximately four- to almost ten-fold the normal values. Copper concentrations in globus pallidus and putamen were also high, 50% more than normal. Calcium, iron, zinc and magnesium concentrations were all normal. The fourth case showed no abnormal intensity in the basal ganglia and brain metal concentrations were all normal. Histopathologically, cases with showing high signal remarkable atrophy, necrosis, and deciduation of nerve cells and proliferation of glial cells and microglia in globus pallidus.. These findings were similar to those in chronic manganese poisoning. On T1-weighted images, copper deposition shows no abnormal intensity. It is therefore inferred that deposition of highly concentrations of manganese may caused high signal on T1-weighted images and nerve cell death in the globus pallidus.
H Maeda; M Sato; A Yoshikawa; M Kimura; T Sonomura; M Terada; K Kishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroradiology     Volume:  39     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-10-23     Completed Date:  1997-10-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  546-50     Citation Subset:  IM    
Department of Radiology, Wakayama Medical College, Japan.
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MeSH Terms
Basal Ganglia / pathology*
Brain / pathology*
Copper / metabolism
Frontal Lobe / pathology
Globus Pallidus / pathology
Hepatic Encephalopathy / diagnosis*
Hepatitis C / diagnosis,  pathology
Liver Cirrhosis / diagnosis*
Magnetic Resonance Imaging*
Manganese / metabolism
Middle Aged
Neuroglia / pathology
Neurons / pathology
Putamen / pathology
Reference Values
Trace Elements / metabolism*
Reg. No./Substance:
0/Trace Elements; 7439-96-5/Manganese; 7440-50-8/Copper

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