| Brain iron deposition and sequence characteristics in parkinsonism: comparison of SWI, T₂* maps, T₂-weighted-, and FLAIR-SPACE. | |
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MedLine Citation:
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PMID: 20829707 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: To compare quantitatively T2- and T2*-based magnetic resonance imaging sequences in patients with symptoms of Parkinson disease and to evaluate the information content of those sequences regarding brain iron concentration. MATERIALS AND METHODS: We imaged 51 patients with symptoms of Parkinson disease on 3-T magnetic resonance imaging with T2-weighted sampling perfection with application optimized contrasts using different flip-angle evolution (SPACE), fluid attenuation inversion recovery (FLAIR)-SPACE, susceptibility-weighted imaging (SWI), and parametric T2* sequence (MapIt). Signal analysis was performed in 22 regions of interest in the brain. RESULTS: Correlations (r2 = 0.82...0.96) with brain iron concentration were excellent. Contrast and tissue separability ratios were best in the T2* maps and FLAIR-SPACE, respectively. Good correlations of contrast were reached between SWI and both T2-weighted SPACE and FLAIR-SPACE. Their relation to quantitative T2* values was reminiscent of a quadratic curve shape. However, separation into gray and white matter revealed a linear positive and negative correlation, respectively. CONCLUSIONS: SWI showed potential in differentiating illnesses characterized by brain iron deposition. Closely similar information was given by T2-weighted SPACE and FLAIR-SPACE, whereas other sequence comparisons revealed dispersion from intersequence agreement. |
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Authors:
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Maija Rossi; Hanna Ruottinen; Irina Elovaara; Pertti Ryymin; Seppo Soimakallio; Hannu Eskola; Prasun Dastidar |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Investigative radiology Volume: 45 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2011-08-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 795-802 Citation Subset: IM |
Affiliation:
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Department of Radiology, Medical Imaging Centre, Tampere University Hospital, Tampere, Finland. maija.rossi@pshp.fi |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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