| Brain IL-6 and PG-dependant actions of IL-1{beta} and lipopolysaccharide in avian fever. | |
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MedLine Citation:
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PMID: 21677266 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is, thus far, no persuasive evidence of a correlation between pro-inflammatory cytokines and avian fever. In this study, for the first time, we use avian cytokines to investigate a role for pro-inflammatory cytokines in the central component of avian fever. Both IL-1β and IL-6 injected intracerebroventricularly (ICV) into Pekin ducks (n = 8) initiated robust fevers of equal magnitude and duration, though there was a significant difference in the latency to a febrile response. In addition, the IL-1β induced fever could be abolished with an ICV injection of antibodies to avian IL-6 (anti-IL-6) or an oral administration of a PG synthesis-inhibitor. Our findings indicate the following sequence of events, within the central component of the avian febrile mechanism: IL-1β gives rise to bioactive IL-6, which stimulates an accelerated synthesis of PGs, and these PGs then adjust the sensitivity of warm sensitive neurons in the avian brain stem to mediate fever. Yet, PGE(2) was not upregulated in the cerebrospinal fluid of ducks made febrile with LPS. We conclude that IL-1β and IL-6 may well mediate fever by instigating an accelerated synthesis of brain-derived PG, of a class other than PGE(2), or that IL-6 serves as one of the terminal mediators of the avian febrile response. |
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Authors:
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Manette Marais; Shane K Maloney; David A Gray |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-15 |
Journal Detail:
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Title: American journal of physiology. Regulatory, integrative and comparative physiology Volume: - ISSN: 1522-1490 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100901230 Medline TA: Am J Physiol Regul Integr Comp Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of the Witwatersrand. |
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