| The brain-gut axis in abdominal pain syndromes. | |
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MedLine Citation:
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PMID: 21090962 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The importance of bidirectional brain-gut interactions in gastrointestinal (GI) illness is increasingly recognized, most prominently in the area of functional GI syndromes such as irritable bowel syndrome (IBS), functional dyspepsia, and functional chest pain. The brain receives a constant stream of interoceptive input from the GI tract, integrates this information with other interoceptive information from the body and with contextual information from the environment, and sends an integrated response back to various target cells within the GI tract. This system is optimized to assure homeostasis of the GI tract during physiological perturbations and to adapt GI function to the overall state of the organism. In health, the great majority of interoceptive information reaching the brain is not consciously perceived but serves primarily as input to autonomic reflex pathways. In patients with functional abdominal pain syndromes, conscious perception of interoceptive information from the GI tract, or recall of interoceptive memories of such input, can occur in the form of constant or recurrent discomfort or pain. This is often associated with alterations in autonomic nervous system output and with emotional changes. A model is proposed that incorporates reported peripheral and central abnormalities in patients with IBS, extrapolates similar alterations in brain-gut interactions to patients with other chronic abdominal pain syndromes, and provides novel treatment targets. |
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Authors:
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Emeran A Mayer; Kirsten Tillisch |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Annual review of medicine Volume: 62 ISSN: 1545-326X ISO Abbreviation: Annu. Rev. Med. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-01-13 Completed Date: 2011-05-17 Revised Date: 2012-02-22 |
Medline Journal Info:
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Nlm Unique ID: 2985151R Medline TA: Annu Rev Med Country: United States |
Other Details:
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Languages: eng Pagination: 381-96 Citation Subset: IM |
Affiliation:
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Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA. emayer@ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdominal Pain
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drug therapy,
physiopathology* Brain / drug effects, physiopathology* Chronic Disease Female Gastrointestinal Diseases / drug therapy, microbiology, physiopathology* Gastrointestinal Motility / drug effects Homeostasis / drug effects Humans Male Mast Cells / drug effects Neuroimmunomodulation / drug effects Spinal Cord / drug effects, physiopathology Syndrome |
| Grant Support | |
ID/Acronym/Agency:
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R01 DK048351-13/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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