Document Detail

Brain dysfunction primarily related to previous overt hepatic encephalopathy compared with minimal hepatic encephalopathy: resting-state functional MR imaging demonstration.
MedLine Citation:
PMID:  23047839     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To investigate whether resting-state brain functional connectivity (FC) differed among cirrhotic patients without overt hepatic encephalopathy (HE) (OHE), those who currently had minimal HE (MHE), or those who had recovered from previous OHE and to investigate whether previous bouts of OHE rather than current MHE predominantly contributed to brain dysfunction in patients without current OHE.
MATERIALS AND METHODS: This study was approved by the institutional ethics committee, and informed consent was obtained. Resting-state functional magnetic resonance (MR) data were compared between healthy controls and the following groups of cirrhotic patients: (a) patients without MHE and without previous OHE, (b) patients with current MHE and without previous OHE, and (c) patients with previous OHE. Independent component analysis was applied to identify the best-fit component for the default-mode network (DMN). One-way analysis of variance was performed to detect different FC among groups. Pearson correlation analyses were conducted to determine the relationships between FC and neurocognitive performance.
RESULTS: Two important regions within the DMN, including the precuneus and posterior cingulate cortex and left medial frontal gyrus, showed significantly different FC among the four groups. A trend of gradually reduced FC in two regions was observed from controls, to patients without HE, and to patients with current MHE, while patients with previous OHE showed remarkably reduced FC in these two regions. Significant correlations were found between FC and neurocognitive performance in cirrhotic patients.
CONCLUSION: The reduced resting-state FC within DMN was associated with neurocognitive impairments in MHE and after clinical resolution of OHE. Previous OHE rather than current MHE might be primarily related to brain dysfunction in patients with latent OHE.
Hua-Jun Chen; Yun Jiao; Xi-Qi Zhu; Hong-Ying Zhang; Jia-Cheng Liu; Song Wen; Gao-Jun Teng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-09
Journal Detail:
Title:  Radiology     Volume:  266     ISSN:  1527-1315     ISO Abbreviation:  Radiology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-02-12     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  261-70     Citation Subset:  AIM; IM    
Copyright Information:
RSNA, 2012
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MeSH Terms
Brain / pathology,  physiopathology*
Brain Mapping / methods*
Cognition Disorders / diagnosis,  etiology*,  physiopathology*
Hepatic Encephalopathy / complications*,  diagnosis,  physiopathology*
Magnetic Resonance Imaging / methods*
Middle Aged
Reproducibility of Results
Sensitivity and Specificity
Severity of Illness Index
Comment In:
Radiology. 2013 Nov;269(2):623   [PMID:  24312938 ]
Radiology. 2013 Nov;269(2):622-3   [PMID:  24155289 ]

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