| Bradykinin pathway is involved in acute hemodynamic effects of enalaprilat in dogs with heart failure. | |
MedLine Citation:
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PMID: 8764248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the role of the renin-angiotensin system and the bradykinin pathway in the mechanism of action of angiotensin-converting enzyme inhibitors in heart failure, the acute effects of enalaprilat (1 mg/kg) were compared with those of a renin inhibitor (ciprokiren, 1 mg/kg i.v.) in 10 chronically instrumented conscious dogs with heart failure induced by right ventricular pacing (3 wk, 240 beats/min). The effects of enalaprilat and ciprokiren on bradykinin infusion (3, 10, and 30 micrograms/min) and the effects of enalaprilat in the presence of the bradykinin B2 receptor antagonist Hoe-140 (10 micrograms/kg i.v.) were also examined. Both inhibitors significantly decreased mean aortic pressure and increased cardiac output. However, enalaprilat induced significantly greater hemodynamic effects than ciprokiren (mean aortic pressure, -13 +/- 3 vs. -6 +/- 1 mmHg; cardiac output, 0.4 +/- 0.1 vs. 0.15 +/- 0.1 l/min). Bradykinin infusion led to dose-dependent decreases in mean aortic pressure and increases in cardiac output that were not modified by pretreatment with ciprokiren but were potentiated 10-fold by enalaprilat. Hoe-140 significantly reduced the hemodynamic effects of enalaprilat. Thus endogenous bradykinin is involved in the acute hemodynamic effects of enalaprilat in experimental heart failure. |
Authors:
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F Barbe; J B Su; T T Guyene; B Crozatier; J Ménard; L Hittinger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 270 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-09-19 Completed Date: 1996-09-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1985-92 Citation Subset: IM |
Affiliation:
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Institut National de la santé et de la Recherche Médicale, Faculté de Médecine, Créteil, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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pharmacology* Animals Bradykinin / analogs & derivatives, metabolism*, pharmacology, physiology Cardiac Output, Low / blood, physiopathology* Dogs Enalaprilat / pharmacology* Female Hemodynamics / drug effects*, physiology Hormones / blood Imidazoles / pharmacology Male Receptors, Bradykinin / antagonists & inhibitors Renin / antagonists & inhibitors Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Hormones; 0/Imidazoles; 0/Receptors, Bradykinin; 130308-48-4/icatibant; 143631-62-3/ciprokiren; 58-82-2/Bradykinin; 84680-54-6/Enalaprilat; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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