| Bradykinin mediates cardiac preconditioning at a distance. | |
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MedLine Citation:
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PMID: 10775135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preconditioning the heart by brief coronary (CAO) or mesenteric artery occlusion (MAO) can protect against damage during subsequent prolonged CAO and reperfusion. The role of bradykinin (BK) in remote cardiac preconditioning by MAO is investigated by antagonizing the BK B(2) receptor [Hoechst 140 (HOE-140)] or simulating local BK release by mesenteric intra-arterial infusion. Anesthetized male Wistar rats (n = 6-8) were treated with HOE-140 or saline before starting the preconditioning protocol, CAO, MAO, or non-preconditioned control. Infarct size related to risk area [ratio of infarct area to area at risk (IA/AR)] was determined after 3 h of reperfusion following a 60-min CAO. IA/AR was 62 +/- 5% in controls and not affected by HOE-140 (58 +/- 6%). CAO as well as MAO significantly protected the heart (IA/AR, 37 +/- 3 and 35 +/- 5%), which was prevented by HOE-140 (IA/AR, 71 +/- 6 and 65 +/- 7%, respectively). Brief intramesenteric BK infusion mimicked MAO (IA/AR, 26 +/- 3%). Pretreatment with hexamethonium could abolish this protection (IA/AR, 67 +/- 4%). These data indicate an important role for BK in remote preconditioning by MAO. Results support the hypothesis that remote preconditioning acts through sensory nerve stimulation in the ischemic organ. |
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Authors:
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R G Schoemaker; C L van Heijningen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 278 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-28 Completed Date: 2000-06-28 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1571-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine and Health Sciences, Erasmus University, NL-3000 DR Rotterdam, The Netherlands. schoemaker@farma.fgg.eur.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology Animals Bradykinin / administration & dosage, analogs & derivatives, metabolism*, pharmacology Coronary Vessels / physiology Dose-Response Relationship, Drug Heart / drug effects, physiology* Hexamethonium / pharmacology Infusions, Intra-Arterial Ischemic Preconditioning, Myocardial* Linear Models Male Mesenteric Arteries / physiology Myocardial Ischemia / metabolism, pathology Myocardium / metabolism, pathology Nicotinic Antagonists / pharmacology Rats Rats, Wistar Receptor, Bradykinin B2 Receptors, Bradykinin / agonists, antagonists & inhibitors Survival Rate |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Nicotinic Antagonists; 0/Receptor, Bradykinin B2; 0/Receptors, Bradykinin; 130308-48-4/icatibant; 58-82-2/Bradykinin; 60-26-4/Hexamethonium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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