Document Detail

Bradykinin involvement in the aggravation of acute pancreatitis in rabbits.
MedLine Citation:
PMID:  7694883     Owner:  NLM     Status:  MEDLINE    
This study was designed to investigate the role of bradykinin in the aggravation of acute pancreatitis. After injection of bradykinin 2 micrograms/kg to anesthetized rabbits with cerulein-induced acute pancreatitis, the pancreatic blood flow through gastroduodenal and superior mesenteric arteries (GDAF and SMAF) was determined with electromagnetic blood flow meters, the serum amylase level was measured, and pancreatic tissue was observed histologically. In rabbits treated with a supramaximal dose of cerulein alone (20 micrograms/kg/h), pancreatic blood flow was decreased and the serum amylase level was increased significantly by the early phase, and histological examination showed acute edematous pancreatitis. In rabbits treated with cerulein and bradykinin, GDAF and SMAF were significantly diminished at 300 min (51 +/- 5% and 50 +/- 4%, respectively, p < 0.05), and the serum amylase level rose significantly at 180 and 300 min (730 +/- 130% and 1,190 +/- 200%, respectively, p < 0.01) compared with rabbits treated with cerulein alone, and histological examination revealed pancreatic necrosis and greater inflammatory cell infiltration. These findings suggest that bradykinin has an additive role in the aggravation of acute pancreatitis.
F Yotsumoto; T Manabe; G Ohshio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestion     Volume:  54     ISSN:  0012-2823     ISO Abbreviation:  Digestion     Publication Date:  1993  
Date Detail:
Created Date:  1994-01-06     Completed Date:  1994-01-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0150472     Medline TA:  Digestion     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  224-30     Citation Subset:  IM    
First Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Acute Disease
Amylases / blood
Bradykinin / pharmacology,  physiology*
Kallikrein-Kinin System / physiology*
Pancreas / blood supply*,  drug effects
Pancreatic Juice / metabolism
Pancreatitis / chemically induced,  physiopathology*
Regional Blood Flow / physiology
Reg. No./Substance:
17650-98-5/Caerulein; 58-82-2/Bradykinin; EC 3.2.1.-/Amylases

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