| Bradykinin inhibits development of myocardial infarction through B2 receptor signalling by increment of regional blood flow around the ischaemic lesions in rats. | |
| | |
MedLine Citation:
|
PMID: 12522094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1 To identify the roles of endogenous kinins in prevention of myocardial infarction (MI), we performed the permanent ligation of coronary artery in rats. 2 The size of MI 12, 24, and 48 h after coronary ligation in kininogen-deficient Brown Norway Katholiek (BN-Ka) rats was significantly larger (49.7+/-0.2%, 49.6+/-2%, and 51.1+/-1%, respectively) than that of kinin-replete Brown Norway Kitasato (BN-Ki) rats (42+/-2%, 38.5+/-4%, and 41.5+/-1%). 3 Hoe140, a bradykinin (BK) B(2) receptor antagonist injected (1.0 mg kg(-1), i.v.) half an hour before, and every 8 h after, coronary ligation, significantly increased the size of MI in Sprague-Dawley rats. Aprotinin, a kallikrein inhibitor, which was infused intravenously (10,000 Units kg(-1) h(-1)) with an osmotic mini-pump, significantly increased the size of an MI 24 h after ligation. 4 When evaluated using microspheres, the regional myocardial blood flow around the necrotic lesion in BN-Ka rats 6 h after ligation was reduced more than that in BN-Ki rats with MI by 41-46%. The same was true in Hoe140-treated BN-Ki rats. 5 FR190997, a nonpeptide B(2) agonist, which was infused (10 microg kg(-1) h(-1)) into the vena cava of BN-Ka rats for 24 h with an osmotic mini-pump, caused significant reduction in the size of MI (38+/-3%), in comparison with the size in vehicle solution-treated rats (51+/-3%). The size of MI in FR190997-treated BN-Ka rats was the same as in BN-Ki rats. 6 These results suggested that endogenous kinin has the capacity to reduce the size of MI via B(2) receptor signalling because of the increase in regional myocardial blood flow around the ischaemic lesion. |
| | |
Authors:
|
Hiroshi Ito; Izumi Hayashi; Tohru Izumi; Masataka Majima |
Related Documents
:
|
8910094 - Visceral fat accumulation and vascular complications associated with vmh lesioning of s... 1370784 - Auditory brain-stem response in zitter rats with genetic spongiform encephalopathy. 1012984 - Effects of lesions of monoaminergic system in the brain on the hypotensive effects of c... 4027694 - Comparison of the metabolic and behavioral disturbances following paraventricular- and ... 1756514 - On the long-term toxic risk of dinaline. 7386304 - Adrenalectomy prevents hypoxic lung histamine accumulation. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: British journal of pharmacology Volume: 138 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2003 Jan |
Date Detail:
|
Created Date: 2003-01-10 Completed Date: 2003-07-15 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
|
Languages: eng Pagination: 225-33 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Kitasato University School of Medicine, Kitasato 1-15-1, Sagamihara, Kanagawa 228-8555, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Bradykinin / metabolism* Coronary Circulation / physiology* Kininogens / deficiency, genetics Male Myocardial Infarction / metabolism*, pathology, prevention & control Myocardial Ischemia / metabolism*, pathology Rats Rats, Inbred BN Rats, Sprague-Dawley Receptor, Bradykinin B2 Receptors, Bradykinin / antagonists & inhibitors, physiology* Signal Transduction / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Kininogens; 0/Receptor, Bradykinin B2; 0/Receptors, Bradykinin; 58-82-2/Bradykinin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Alpha 1-adrenoceptor effects mediated by protein kinase C alpha in human cultured prostatic stromal ...
Next Document: Monovalent cation (MC) current in cardiac and smooth muscle cells: regulation by intracellular Mg2+ ...