| Bradykinin causes a prolonged increase in skin microvascular permeability. | |
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MedLine Citation:
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PMID: 3747490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bradykinin is an endogenous inflammatory mediator, and its mechanism of action is incompletely understood. It is controversial whether bradykinin causes a sustained increase in microvascular permeability, or has only a transient effect. In anesthetized dogs intraarterial infusion of bradykinin (0.14 to 0.54 micrograms/kg/min) produced an immediate increase in flow of protein-rich, hindpaw lymph. After 210 min of bradykinin infusion lymph flow was threefold greater than baseline, lymph protein concentration remained doubled, and in a dose-related fashion bradykinin produced a sustained increase in lymph protein flux. Lymph flow was then further increased with venous hypertension, and after 4 hr lymph protein flux remained greater from the bradykinin paws than from the control paws. This sustained increase in protein flux indicates that bradykinin produces an increase in permeability at the microvascular membrane by a mechanism that is different from how the initial increase in permeability was produced. |
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Authors:
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R J Mullins |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The Journal of surgical research Volume: 40 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1986 Jun |
Date Detail:
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Created Date: 1986-10-20 Completed Date: 1986-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 540-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Bradykinin / pharmacology* Dogs Lymph / analysis, drug effects Lymphatic System / drug effects* Male Proteins / analysis Rabbits Skin / drug effects*, immunology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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