Document Detail

Bradykinin causes a prolonged increase in skin microvascular permeability.
MedLine Citation:
PMID:  3747490     Owner:  NLM     Status:  MEDLINE    
Bradykinin is an endogenous inflammatory mediator, and its mechanism of action is incompletely understood. It is controversial whether bradykinin causes a sustained increase in microvascular permeability, or has only a transient effect. In anesthetized dogs intraarterial infusion of bradykinin (0.14 to 0.54 micrograms/kg/min) produced an immediate increase in flow of protein-rich, hindpaw lymph. After 210 min of bradykinin infusion lymph flow was threefold greater than baseline, lymph protein concentration remained doubled, and in a dose-related fashion bradykinin produced a sustained increase in lymph protein flux. Lymph flow was then further increased with venous hypertension, and after 4 hr lymph protein flux remained greater from the bradykinin paws than from the control paws. This sustained increase in protein flux indicates that bradykinin produces an increase in permeability at the microvascular membrane by a mechanism that is different from how the initial increase in permeability was produced.
R J Mullins
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of surgical research     Volume:  40     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-9     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Bradykinin / pharmacology*
Lymph / analysis,  drug effects
Lymphatic System / drug effects*
Proteins / analysis
Skin / drug effects*,  immunology
Time Factors
Reg. No./Substance:
0/Proteins; 58-82-2/Bradykinin

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