| Bradykinin antagonism and prostaglandins in blood pressure regulation. | |
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MedLine Citation:
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PMID: 2567708 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These experiments were designed to analyze the interaction of a bradykinin antagonist with prostaglandins in blood pressure regulation of normotensive rats. Male Wistar rats, divided into three groups, received a 5-minute intra-arterial infusion of the bradykinin antagonist [( DArgo-Hyp3-Thi5,8-DPhe7]BK-TFA) at 250 micrograms/min. Groups were either intact rats (group I, n = 5), pretreated with indomethacin (group II, n = 10), or pretreated with both indomethacin and prazosin (group III, n = 8). The bradykinin antagonist infusion, which was shown to inhibit exogenous bradykinin by greater than 76% in intact animals, did not alter mean arterial pressure in group I rats despite a twofold increase in norepinephrine and a threefold increase in epinephrine. Group II rats presented a progressive increase in mean arterial pressure during the bradykinin antagonist infusion (14 +/- 3 mm Hg), with no statistically significant change in plasma catecholamines. Group III, with lower baseline mean arterial pressure due to alpha 1-adrenergic blockade, had an increase in mean arterial pressure comparable with group II during bradykinin antagonist infusion (22 +/- 5 mm Hg), confirming that this response was not sympathetically mediated. We conclude that in normotensive rats bradykinin plays a role in blood pressure regulation that is closely linked to that of prostaglandins and that points to a balance between these systems. |
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Authors:
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R Mulinari; I Gavras; R Franco; H Gavras |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Hypertension Volume: 13 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-08-08 Completed Date: 1989-08-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 960-3 Citation Subset: IM |
Affiliation:
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Department of Medicine, Boston City Hospital, Massachusetts. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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pharmacology Animals Blood Pressure* Bradykinin / analogs & derivatives, antagonists & inhibitors*, pharmacology Cyclooxygenase Inhibitors Heart Rate / drug effects Indomethacin / pharmacology Male Prazosin / pharmacology Prostaglandins / physiology* Rats Rats, Inbred Strains |
| Grant Support | |
ID/Acronym/Agency:
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18318//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Cyclooxygenase Inhibitors; 0/Prostaglandins; 103412-42-6/B 4162; 19216-56-9/Prazosin; 53-86-1/Indomethacin; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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