Document Detail

Bradykinin antagonism and prostaglandins in blood pressure regulation.
MedLine Citation:
PMID:  2567708     Owner:  NLM     Status:  MEDLINE    
These experiments were designed to analyze the interaction of a bradykinin antagonist with prostaglandins in blood pressure regulation of normotensive rats. Male Wistar rats, divided into three groups, received a 5-minute intra-arterial infusion of the bradykinin antagonist [( DArgo-Hyp3-Thi5,8-DPhe7]BK-TFA) at 250 micrograms/min. Groups were either intact rats (group I, n = 5), pretreated with indomethacin (group II, n = 10), or pretreated with both indomethacin and prazosin (group III, n = 8). The bradykinin antagonist infusion, which was shown to inhibit exogenous bradykinin by greater than 76% in intact animals, did not alter mean arterial pressure in group I rats despite a twofold increase in norepinephrine and a threefold increase in epinephrine. Group II rats presented a progressive increase in mean arterial pressure during the bradykinin antagonist infusion (14 +/- 3 mm Hg), with no statistically significant change in plasma catecholamines. Group III, with lower baseline mean arterial pressure due to alpha 1-adrenergic blockade, had an increase in mean arterial pressure comparable with group II during bradykinin antagonist infusion (22 +/- 5 mm Hg), confirming that this response was not sympathetically mediated. We conclude that in normotensive rats bradykinin plays a role in blood pressure regulation that is closely linked to that of prostaglandins and that points to a balance between these systems.
R Mulinari; I Gavras; R Franco; H Gavras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hypertension     Volume:  13     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-08-08     Completed Date:  1989-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  960-3     Citation Subset:  IM    
Department of Medicine, Boston City Hospital, Massachusetts.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology
Blood Pressure*
Bradykinin / analogs & derivatives,  antagonists & inhibitors*,  pharmacology
Cyclooxygenase Inhibitors
Heart Rate / drug effects
Indomethacin / pharmacology
Prazosin / pharmacology
Prostaglandins / physiology*
Rats, Inbred Strains
Grant Support
18318//PHS HHS
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Cyclooxygenase Inhibitors; 0/Prostaglandins; 103412-42-6/B 4162; 19216-56-9/Prazosin; 53-86-1/Indomethacin; 58-82-2/Bradykinin

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