Document Detail


Bradykinin analogs containing alpha-aminoisobutyric acid (Aib).
MedLine Citation:
PMID:  7232227     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
All seven possible bradykinin (BK) analogs contained Aib in place of proline have been synthesized by the solid phase method and assayed for in vitro myotropic activity on the guinea pig ileum and rat uterus, and in vivo on the rat blood pressure, both in intravenous and intra-aortic administration. [Aib(2,3)]-BK, [Aib(2,7)]-BK, and [Aib(2,3,7)]-BK had no in vivo or in vitro activities; [Aib(2)]-BK, [Aib(3)]-BK and [Aib(3,7)]-BK had moderate BK-like activities and a significantly increased resistance to pulmonary inactivation in the rat ([Aib(3,7)]-BK was totally resistant). [Aib(7)]-BK was found to be the most active position seven BK analog yet assayed on the rat blood pressure, and shows remarkably high ileum (4 times BK) and intravenous rat blood pressure (6 times BK) activity.
Authors:
R J Vavrek; J M Stewart
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  1     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1980  
Date Detail:
Created Date:  1981-07-20     Completed Date:  1981-07-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  231-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aminoisobutyric Acids
Animals
Blood Pressure / drug effects
Bradykinin / analogs & derivatives*,  chemical synthesis,  pharmacology
Female
Guinea Pigs
Ileum / drug effects
Indicators and Reagents
Muscle Contraction / drug effects
Rats
Structure-Activity Relationship
Uterine Contraction / drug effects
Grant Support
ID/Acronym/Agency:
1-HV-72946/HV/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aminoisobutyric Acids; 0/Indicators and Reagents; 58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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