| Bradykinin analogs containing alpha-aminoisobutyric acid (Aib). | |
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MedLine Citation:
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PMID: 7232227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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All seven possible bradykinin (BK) analogs contained Aib in place of proline have been synthesized by the solid phase method and assayed for in vitro myotropic activity on the guinea pig ileum and rat uterus, and in vivo on the rat blood pressure, both in intravenous and intra-aortic administration. [Aib(2,3)]-BK, [Aib(2,7)]-BK, and [Aib(2,3,7)]-BK had no in vivo or in vitro activities; [Aib(2)]-BK, [Aib(3)]-BK and [Aib(3,7)]-BK had moderate BK-like activities and a significantly increased resistance to pulmonary inactivation in the rat ([Aib(3,7)]-BK was totally resistant). [Aib(7)]-BK was found to be the most active position seven BK analog yet assayed on the rat blood pressure, and shows remarkably high ileum (4 times BK) and intravenous rat blood pressure (6 times BK) activity. |
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Authors:
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R J Vavrek; J M Stewart |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Peptides Volume: 1 ISSN: 0196-9781 ISO Abbreviation: Peptides Publication Date: 1980 |
Date Detail:
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Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008690 Medline TA: Peptides Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 231-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminoisobutyric Acids Animals Blood Pressure / drug effects Bradykinin / analogs & derivatives*, chemical synthesis, pharmacology Female Guinea Pigs Ileum / drug effects Indicators and Reagents Muscle Contraction / drug effects Rats Structure-Activity Relationship Uterine Contraction / drug effects |
| Grant Support | |
ID/Acronym/Agency:
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1-HV-72946/HV/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aminoisobutyric Acids; 0/Indicators and Reagents; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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